● Gịnị BụSclareol ?
Sclareol, aha kemịkal (1R,2R,8aS) -decahydro-1- (3-hydroxy-3-methyl-4-pentenyl) -2,5,5,8a-tetramethyl-2-naphthol, usoro molecular C₂₀H₃₆O₂, molecular arọ 308.2501,308AS-nọmba 308.250-308AS. Ọ bụ ogige diterpenoid bicyclic, nke nwere ọdịdị ọcha kristal ntụ ntụ, ebe agbaze 95-105 ℃, ebe esi mmiri 398.3 ℃, enweghị ike ime na mmiri, yana ngwa ngwa soluble na ihe mgbaze organic. Ihe e ji mara ya bụ na ọ na-esi ísì ụtọ na-adịte aka dị ka ambergris, na-esi ísì ụtọ na mgbasa siri ike, na-eme ka ọ bụrụ ihe dị mma maka ihe na-esi ísì ụtọ.
The eke isi iyi bụ tumadi inflorescence na ị ga na epupụta nke Lamiaceae osisi Salvia Sclarea L., nke a na-akọ na nnukwu ọnụ ọgụgụ na elu ugwu ugwu dị ka ugwu Shaanxi na Honghe, Yunnan, China. N'ihi nnukwu ọdịiche dị n'etiti ehihie na abalị na iru mmiri kwesịrị ekwesị, clarysol dị n'ebe ndị a na-emepụta ihe dị ọcha na isi ísì.
E nwere ọtụtụ isi ụzọ maka synthesizing sclareol:
1. Ngwakọta kemịkalụ
N'ozuzu,clareola na-eji mpụta dị ka akụrụngwa maka mmịpụta na ime ka ọ dị ọcha. Ihe fọdụrụ na sclareol mgbe mwepu mmanụ na-agbaze na ethanol, na sclareol na-agbanye n'ụdị agịga ọcha mgbe obere okpomọkụ na-ekpo ọkụ, nzacha, ọgwụgwọ carbon na-arụ ọrụ, dilution na usoro ndị ọzọ. Mgbe akpịrị ịkpọ nkụ centrifugal gasịrị, ihicha agụụ, ihichapụ na nyocha, enwere ike nweta sclareol nwere nnukwu mmanya na-aba n'anya.
2. Biosynthesis
Ịrụ ụlọ ọrụ yist cell ụlọ ọrụ brewer: N'ọmụmụ ihe, a na-ejikọta synthases abụọ TPS na LPP na sage na mkpụrụ ndụ ihe nketa yist, bụ nke mụbara mmepụta nke ọma.clareol. Mgbe ahụ, ejikọrọ N-terminus nke TPS-LPPS na akụkụ nke protein na-ejikọta maltose iji mee ka nkwụsi ike nke enzyme ahụ dịkwuo mma ma mụbaa mkpụrụ ọzọ. Mgbe ahụ, ndị otu nyocha kewara ụzọ usoro metabolic niile n'ime modul atọ: okporo ụzọ metabolic etiti maka ịnye acetyl coenzyme A, ụzọ biosynthesis isoprenoid na modul ihe na-achịkwa maka mgbanwe usoro. Site n'ọnọdụ mweghachi na ihichapụ ụfọdụ mkpụrụ ndụ ihe nketa metụtara ya, a rụpụtara ụdị chassis nke nwere ike ịnye acetyl-CoA na NADPH nke ọma, na mkpụrụ nke sclareol na-emewanyewanye ya site n'iwepụ mkpụrụ ndụ ihe nketa ụfọdụ. N'ikpeazụ, a na-enyocha mmetụta nke modul ọ bụla na njikọ nke sclareol site na profaịlụ nke metabolic nke ụdị engineered, ma chọpụta na modul atọ ahụ nwere mmetụta synergistic. A na-eme gbaa ụka Fed-batch na shake flasks na bioreactors, na n'ikpeazụ, sclareol na-arụ ọrụ nke ọma na Saccharomyces cerevisiae site na iji glucose dị ka akụrụngwa, na-enwe 11.4 g/L.
●Kedu ihe bụUruNke Sclareol ?
Nnyocha e mere n'oge na-adịbeghị anya ekpughere ọrụ dị iche iche nke sclareol, karịsịa na ngalaba nke ọrịa usoro nhụjuanya nke etiti:
1. Mgbochi mkpali na neuroprotective:
Na-egbochi oke ịgbalite microglia, na-ebelata ọkwa nke ihe mkpali TNF-a na IL-1β, na-ebelata nsogbu mmegharị na oke oke ihe atụ nke Parkinson, ma na-echebe neurons dopamine;
Melite ọrụ ọgụgụ isi na ụdị ọrịa Alzheimer. Otu dose nke 50-200mg/(kg·d) nwere ike igbochi ịgbalite astrocytes n'ụbụrụ ma belata ntinye nke protein β-amyloid.
2. Ọrụ mgbochi ọrịa kansa:
Ọ nwere cytotoxicity siri ike na ahịrị mkpụrụ ndụ kansa dị ka leukemia òké (P-388) na carcinoma epidermal mmadụ (KB), ma na-egbochi mmụba nke etuto ahụ site na ịkpata apoptosis.
3. Antibacterial na antioxidant:
Ọ nwere ụdị dị iche iche nke igbochi uto nje, yana arụmọrụ antioxidant ya dị okpukpu 50 karịa nke vitamin E, nke dabara maka akwa ọnya na ngwaahịa nlekọta anụ ahụ na-egbochi ịka nká.
●Kedu ihe bụNgwaOf Sclareol ?
1. Ụlọ ọrụ ire ụtọ na isi ísì:
Dị ka isi akụrụngwa maka njikọ nke ambergris, ọ na-anọchi ambergris eke sitere na sperm whales nọ n'ihe ize ndụ. A na-eji obere ego eme ihe ozugbo na ihe na-esi ísì ụtọ dị elu iji nye ísì ụtọ na-adịgide adịgide.
2. Nchọpụta na mmepe nke ọgwụ:
Ọrịa Alzheimer / Ọgwụ ọrịa Parkinson: capsules ọnụ ma ọ bụ injections abanyela nyocha nke ọma, na-ezubere igbochi neuroinflammation;
Ọgwụ mgbochi ọrịa cancer adjuvant: jikọtara ya na ọgwụ chemotherapy iji kwalite igbu egbu mkpụrụ ndụ tumo.
3. Ihe ịchọ mma na nri:
Ngwaahịa nlekọta akpụkpọ ahụ na-egbochi ịka nká: tinye 0.5% -2% iji gbochie fotoaging ma belata ultraviolet erythema;
Ihe nchekwa eke: eji ya na nri mmanu mmanu iji gbatịa ndụ nchekwa, ma dịkwa mma karịa ngwaahịa sịntetik kemịkalụ.
●Ọdịmma dị elu NEWGREENSclareolNtụ ntụ
Oge nzipu: Jun-25-2025
