● Gịnị bụChenodeoxycholic acid ?
Chenodeoxycholic acid (CDCA) bụ otu n'ime ihe ndị bụ isi nke bile vertebrate, na-aza 30%-40% nke bile acid mmadụ, ọdịnaya ya dịkwa elu na bile nke geese, ọbọgwụ, ezì na anụmanụ ndị ọzọ.
Ọganihu na teknụzụ mmịpụta ọgbara ọhụrụ:
Ihe dị egwu CO₂ mmịpụta: mmịpụta n'okpuru obere okpomọkụ na ọnọdụ nrụgide dị elu iji zere ihe ndị na-agbaze organic, na ịdị ọcha nwere ike iru karịa 98%;
Usoro ịgba ụka Microbial: iji ụdị mkpụrụ ndụ ihe nketa (dị ka Escherichia coli) na-emepụta CDCA, ọnụ ahịa ya na-ebelata site na 40%, nke kwekọrọ na usoro nke mmepụta ọgwụ na-acha akwụkwọ ndụ akwụkwọ ndụ;
Usoro njikọ kemịkalụ: iji kọlestrọl dị ka ihe mbido, a na-enweta ya site na mmeghachi omume ọtụtụ nzọụkwụ, dabara maka ngwaahịa ọkwa ọgwụ dị elu.
Njirimara anụ ahụ na chemical nkeChenodeoxycholic acid :
Aha kemịkal: 3α,7α-dihydroxy-5β-cholanic acid (Chenodeoxycholic Acid)
Usoro ihe omimi: C₂₄H₄₀O₄
Ibu ibu: 392.58 g/mol
Ọdịdị: ọcha crystalline ntụ ntụ
Solubility: ubé soluble na mmiri, mfe solubility na ethanol, ether, chloroform
Ebe mgbaze: 165-168 ℃
Nkwụsi ike: na-enwe mmetụta maka ọkụ na okpomọkụ, ọ dị mkpa ka etinye ya na friji pụọ na ìhè (2-8 ℃)
● Gịnị bụ uru nkeChenodeoxycholic acid ?
1. Mgbasa nke Cholesterol Gallstones
Mechanism: na-egbochi imeju HMG-CoA reductase, belata njikọ cholesterol, na-akwalite secretion bile acid, ma jiri nwayọọ nwayọọ gbarie gallstones cholesterol;
Data ụlọ ọgwụ: 750mg CDCA kwa ụbọchị maka ọnwa 12-24, ọnụego mgbasa gallstone nwere ike iru 40%-70%.
2. Ọgwụgwọ nke biliary cholangitis nke mbụ (Pbc)
Ọgwụ nke mbụ: FDA kwadoro Chenodeoxycholic Acid CDCA maka PBC, kwalite ọrụ ọrụ imeju (ALT/AST belatara karịa 50%);
Ngwakọta ọgwụgwọ: jikọtaraChenodeoxycholic acidna ursodeoxycholic acid (UDCA), a na-eme ka ọ dị mma site na 30%.
3. Iwu nke Ọrịa Metabolic
Mbelata lipids ọbara: mbelata serum mkpokọta cholesterol (TC) na lipoprotein dị obere (LDL);
Mgbochi ọrịa shuga: imeziwanye mmetụta insulin, nnwale anụmanụ na-egosi na shuga ọbara na-agbada site na 20%
4. Mgbochi mgbochi na mgbochi ọrịa
Na-egbochi ụzọ NF-κB ma belata ntọhapụ nke ihe ndị na-egbuke egbuke (TNF-α, IL-6);
Nnwale ụlọ ọgwụ egosila na mmụba nke fibrosis imeju na ndị ọrịa nwere ọrịa imeju na-adịghị egbu egbu (NAFLD) karịrị 60%.
● Gịnị bụ ngwa nkeChenodeoxycholic acid ?
1. Medical Field
Ọgwụgwọ gallstone: mbadamba CDCA (250mg / mbadamba), dose kwa ụbọchị 10-15mg / kg;
Ọgwụgwọ PBC: nkwadebe ngwakọta na UDCA (dị ka Ursofalk®), ire ahịa kwa afọ zuru ụwa ọnụ gafere US $ 500 nde;
Nnyocha nyocha nke tumor: igbochi mmụba mkpụrụ ndụ cancer imeju site na ịhazi ndị na-anabata FXR, na-abanye ule ụlọ ọgwụ nke Abụọ.
2. Nri na ngwaahịa ahụike na-arụ ọrụ
Mbadamba ihe nchebe imeju: usoro ihe mejupụtara (CDCA + silymarin), na-ebelata mmebi imeju mmanya;
Capsules na-eweda egbugbere ọnụ: synergistic na mpụta osikapa yist na-acha ọbara ọbara iji mezie metabolism lipid ọbara.
3. Azụ anụ na Aquaculture
Ihe mgbakwunye nri: meziwanye metabolism anụ ụlọ na anụ ọkụkọ, belata ọnụego abụba afọ;
Ahụ ike azụ: na-agbakwunye 0.1%chenodeoxycholic acidiji welie nguzogide ọrịa carp ma welie ọnụ ọgụgụ nlanarị site na 15%.
4. Ihe ịchọ mma na nlekọta onwe onye
Ihe mgbochi mkpali: 0.5% -1% mgbakwunye, meziwanye ihe otutu na anụ ahụ;
Nlekọta akpụkpọ ụkwụ: gbochie Malassezia ma belata ọgbọ dandruff.
Site na mmịpụta bile ọdịnala gaa na njikọ microbial, chenodeoxycholic acid na-enwe mgbanwe site na “ihe sitere n'okike” gaa na “ọgwụgwọ ziri ezi”. Site na nyocha miri emi banyere ọrịa metabolic na mgbochi tumor, CDCA nwere ike bụrụ isi akụrụngwa maka ọgwụgwọ ọrịa imeju, nri na-arụ ọrụ na biomaterials, na-eduga ọhụụ ọhụrụ nke ụlọ ọrụ ahụike ijeri 100.
● Enyemaka ỌhụrụChenodeoxycholic acidNtụ ntụ
Oge nzipu: Jun-11-2025
