●Gịnị bụ Caffeic acid?
Caffeic acid, aha kemịkalụ 3,4-dihydroxycinnamic acid (usoro ihe omimi C₉H₈O₄, CAS No. 331-39-5), bụ ngwakọta phenolic acid sitere n'okike nke a na-ahụkarị na osisi. Ọ bụ kristal edo edo n'ọdịdị, soluble dị ntakịrị na mmiri oyi, na-agbaze ngwa ngwa na mmiri ọkụ, ethanol na ethyl acetate, yana ebe agbaze nke 194-213 ℃ (usoro dị iche iche dịgasị iche iche), oroma-acha ọbara ọbara na ngwọta alkaline, na akwụkwọ ndụ akwụkwọ ndụ gbara ọchịchịrị na kọntaktị na ferric chloride.
Isi mmalite mmịpụta gụnyere:
●Osisi ọgwụ:Asteraceae Solidago, cinnamon, dandelion (nwere caffeic acid ≥ 0.02%), Ranunculaceae Cimicifuga rhizome;
●Akụrụngwa mkpụrụ osisi na akwụkwọ nri:lemon bee, blueberry, apple, broccoli na cruciferous inine;
●Ihe ọṅụṅụ:kọfị kọfị (n'ụdị chlorogenic acid esters), mmanya (conjugated na tartaric acid).
Teknụzụ ọgbara ọhụrụ na-eji teknụzụ CO₂ dị egwu ma ọ bụ teknụzụ bio-enzymatic hydrolysis iji sachaa caffeic acid site na akụrụngwa osisi, yana ịdị ọcha karịa 98%, na-ezute ụkpụrụ ọkwa ọgwụ na ịchọ mma.
● Gịnị Bụ Uru Ọbara Caffeic acid?
Caffeic acid na-egosipụta ọtụtụ ọrụ ndu n'ihi nhazi o-diphenolic hydroxyl ya:
1. Antioxidant na mgbochi mkpali:
O nwere ikike nchacha nke radical kachasị ike n'etiti cinnamic acid hydrogenated, yana arụmọrụ ya dị okpukpu anọ karịa nke vitamin E. Ọ na-egbochi mmeghachi omume nrịanrịa lipid peroxidation site n'ịmepụta ihe owuwu quinone;
Na-egbochi njikọ nke leukotriene (na-achịkwa ihe mgbochi na mbufụt), na-ebelata mmebi DNA akpụkpọ anụ UV, ma na-ebelata ntinye erythema site na 50%.
2. Nchekwa metabolic na obi:
Caffeic acidNa-egbochi lipoproteins dị ala (LDL) oxidation ma na-ebelata nhazi plaque atherosclerotic;
N'ime nnwale òké nri nwere oke abụba, mkpokọta abụba visceral belatara site na 30% yana triglycerides imeju belatara site na 40%.
3. Neuroprotection na mgbochi tumor:
Ngosipụta insulin hippocampal kwalitere, arụ ọrụ ebe nchekwa dị mma na ụdị ọrịa Alzheimer, yana mbelata ntinye protein β-amyloid;
Na-egbochi mgbasa nke mkpụrụ ndụ kansa fibrosarcoma ma na-egbochi uto tumor site na ibelata DNA methylation.
4. Hemostasis na leukocyte na-abawanye:
Ọ na-ebelata microvessels ma na-eme ka ọrụ nke ihe coagulation dịkwuo mma. A na-eji ya n'ụlọ ọgwụ maka hemostasis ịwa ahụ na leukopenia mgbe chemotherapy gasịrị, yana ọnụego dị irè karịa 85%.
● Gịnị bụ ngwa nke Caffeic acid ?
Ngwa nke caffeic acid na-ekpuchi ọtụtụ ubi:
1. Ọgwụ:mbadamba caffeic acid (hemostasis, mmụba nke mkpụrụ ndụ ọbara ọcha), ọgwụ ezubere iche maka ọrịa tumor (nnwale ụlọ ọgwụ nke succinic Phase II)
2. Ihe ịchọ mma:sunscreen (zinc oxide synergistic iji mụbaa uru SPF), ihe na-acha ọcha (na-egbochi tyrosinase, ọnụego mgbochi melanin 80%).
3. Ụlọ ọrụ nri:ihe nchekwa eke (na-egbu oge lipid oxidation azụ), ihe ọṅụṅụ na-arụ ọrụ (mgbochi oxidation na mgbochi mkpali), ojiji nke ascorbic acid synergistic.
4. Ọrụ ugbo na nchekwa gburugburu:pesticides gburugburu ebe obibi (na-egbochi owu bollworm protease), mgbanwe nke ajị anụ (ihe antioxidant mụbara site na 75%)
●Iwu ojiji na nchekwaNkeCaffeic acid
Usoro ọgwụgwọ:Mbadamba ụrọ caffeic acid: 0.1-0.3g otu ugboro, ugboro 3 n'ụbọchị, ụbọchị 14 dị ka usoro ọgwụgwọ, ọ dị mkpa ka a nyochaa ọnụ ọgụgụ platelet (belata mgbe> 100 × 10⁹ / L, ọ dị mkpa ịkpọtụrụ dọkịta tupu iji ya);
Contraindications:Contraindicated maka ụmụ nwanyị dị ime na ndị ọrịa nwere ọnọdụ hypercoagulable; ejiri nlezianya mee ihe na ndị ọrịa nwere ọrịa imeju na ọnya afọ.
Ihe mgbakwunye ịchọ mma:0.5% -2% agbakwunyere na ngwaahịa na-acha ọcha, gbazere na ethanol wee tinye ya na matrix mmiri iji zere agglomeration.
Achọrọ nchekwa:mechie n'ebe gbara ọchịchịrị, refrigerated na 2-8 ℃, dị irè maka afọ 2 (ọ dị mkpa ka echebekwa nkwadebe mmiri site na oxidation na mmebi)
●Nnweta NEWGREENCaffeic acidNtụ ntụ
Oge nzipu: Jul-23-2025
