●Gịnị bụ Bilirubin?
Bilirubin bụ ngwaahịa sitere na mwepu nke mkpụrụ ndụ ọbara uhie merela agadi. Ihe dị ka nde mkpụrụ ndụ ọbara uhie abụọ na-agbasa na splin kwa ụbọchị. Hemoglobin a tọhapụrụ na-agbanwe na-enzymatically ghọọ abụba-soluble bilirubin na-apụtaghị ìhè, bụ nke a na-atụgharị ghọọ bilirubin mmiri na-agbaze ozugbo site na imeju ma mesịa banye n'ime eriri afọ site na bile. Ọdịiche ọ bụla dị na agbụ metabolic a (dị ka hemolysis, mmebi imeju ma ọ bụ mgbochi bile duct) nwere ike ibute mkpokọta bilirubin wee bute jaundice.
Nchọpụta kachasị ọhụrụ chọpụtara na mgbe mkpokọta bilirubin dị≥17.05μmol/L, enwere ike igbochi njikọ dị n'etiti ọrịa shuga na ọrịa strok, yana ohere nke ọrịa strok na ndị ọrịa shuga na-ebelata ugboro 2.67. Usoro a bụ iji gbochie protein C-reactive dị elu na nrịanrịa na-egbu egbu, na-etinye breeki na "oké ifufe ahụ".
A na-ewepụta Bilirubin site na ezì na imeju shark, gallbladder ehi na ụbụrụ ụbụrụ. Anyị enwetala ọganihu site na teknụzụ ọhụrụ:
Mwepụta CO₂ dị egwu: na-ejigide ihe ndị na-arụ ọrụ n'okpuru ọnọdụ okpomọkụ dị ala, zere ihe mgbaze, na ịbawanye ịdị ọcha karịa 98%;
Usoro enzymatic hydrolysis nke ndu: ntụgharị ntụzịaka nke bilirubin glycosides n'ime aglycones na-arụ ọrụ, na-abawanye bioavailability site na 50%.
●Gịnị bụ uru nkeBilirubin ?
1. Nchekwa antioxidant
Bilirubin bụ ihe antioxidant dị mkpa na-eme ka ahụ dị n'ime ahụ, nke nwere ike iwepụ radicals n'efu (dị ka superoxide na hydrogen peroxide) ma belata mmebi nke nrụgide oxidative na membranes cell, protein na DNA. Nnyocha e mere egosiwo na ntanye nke bilirubin dị ala nwere ike ime ka nchebe cell na-echebe megide mmebi oxidative site n'ịgbalite ụzọ mgbaàmà antioxidant (dị ka ụzọ Nrf2), ma nwee ike belata ohere nke atherosclerosis na ọrịa neurodegenerative.
2. Immunomodulatory ọrụ
Bilirubinnwere ike ịhazi nzaghachi mgbochi ọrịa site na igbochi ntọhapụ nke ihe ndị na-egbu egbu (dị ka TNF-a na IL-6). Ọ nwere ike ibelata mmebi nke anụ ahụ kpatara oke mbufụt ma na-echekwa nguzozi nke usoro ahụ ji alụso ọrịa ọgụ. Dịka ọmụmaatụ, mmụba nke bilirubin dị nro na jaundice physiological nke ụmụ amụrụ ọhụrụ nwere ike inye aka belata ohere nke ibute ọrịa site na usoro a. Otú ọ dị, oke ntinye uche nwere ike igbochi ọrụ nke mkpụrụ ndụ na-alụso ọrịa ọgụ ma mee ka ọ nwee ike ibute ọrịa.
3. Cell na neuroprotection
Bilirubin nwere mmetụta nchebe pụrụ iche na usoro ụjọ ahụ. Ọ nwere ike gafere ihe mgbochi ụbụrụ-ọbara ma chebe neurons site na ischemia ma ọ bụ ọnya mmebi site na igbochi glutamate excitotoxicity na ibelata mmebi oxidative. Na mgbakwunye, bilirubin nwekwara ike ibelata mmebi nke mkpụrụ ndụ imeju, mkpụrụ ndụ myocardial, wdg n'okpuru hypoxia ma ọ bụ nsí, ma nọgide na-arụ ọrụ akụkụ ahụ.
4. kwalite metabolism na excretion okirikiri
Usoro metabolic nkebilirubinbụ njikọ dị mkpa n'imegharị haemoglobin n'ime ahụ. Mgbe hemoglobin na-eme agadi nke mkpụrụ ndụ ọbara uhie na-aghọ bilirubin, ọ dị mkpa ijikọ ya na imeju ma wepụ ya n'ime eriri afọ site na bile. Nje bacteria na-eme ka eriri afọ na-agbanwe ya ka ọ ghọọ urobilinogen, nke akụkụ ya na-emegharịghachi (nrịa hepatic), nke fọdụrụ na-esi na nsị. Usoro a abụghị naanị na-enyere aka wepụ ihe mkpofu nke metabolic, kamakwa na-emekọ ihe na osisi intestinal iji metụta nguzozi metabolic n'ozuzu ya.
5. Mmebi nke ọkwa na-adịghị mma
Oke bilirubin: Ọ nwere ike ibute jaundice (acha odo odo nke akpụkpọ ahụ na sclera), nke a na-ahụkarị na ịba ọcha n'anya, mgbochi biliary ma ọ bụ ọrịa hemolytic. Mgbe bilirubin n'efu dị elu nke ukwuu, ọ nwere ike ịgafe ihe mgbochi ụbụrụ ọbara wee bute kernicterus ọhụrụ (mmebi ụbụrụ).
Bilirubin dị obere: Nnyocha e mere n'oge na-adịbeghị anya achọpụtala na mmụba dị nwayọọ na bilirubin nwere ike inwe mmetụta nchebe, ebe oke dị ala nwere ike jikọta ya na ihe ize ndụ dị ukwuu nke ọrịa obi na ọrịa autoimmune, ma usoro a kapịrị ọnụ ka kwesịrị ka a mụọ ya.
●Kedu ihe bụ mmụba ngwa ahụike nke Bilirubin ?
1. Isi akụrụngwa ọgwụ
Bilirubin bụ akụkụ bụ isi nke bezoar artificial ma jiri ya mee ihe na ọgwụ karịrị 130, dị ka ọgwụ obi na ụbụrụ cerebrovascular (85% dị irè n'ibelata ọrịa obi obi) na nhazi usoro nhazi nke menopause.
2. Nkwadebe Nano (BRNPs)
Site na teknụzụ nanocarrier, arụmọrụ na ebumnuche nke bilirubin emeela ka ọ dịkwuo mma:
Ọnya afọ na-egbu egbu: chitosan-bilirubin (CS-BR), na-egbochi mmepụta nke ihe mkpali ma na-akwalite mmụba mucosal.
Imeju abụba na-adịghị egbu egbu: polyethylene glycol-bilirubin (PEG-BR), na-ebelata mkpokọta abụba imeju site na 30%, ma na-ebelata triglycerides site na 40%
Psoriasis: hydrogel.bilirubin, na-eme ka ọnya anụ ahụ dịkwuo mma, na-enweghị nsí sistemu nke corticosteroids
Ọrịa strok: TRPM2 channel inhibitor A23, na-egbochi bilirubin neurotoxicity ma belata nha infarct..
Ngwa ndị ọzọ nke bilirubin: ịzụ anụmanụ, nchekwa gburugburu ebe obibi na ngwaahịa arụ ọrụ
Aquaculture: Ịtinye 4% bilirubin na-eri nri na-abawanye mmepụta nke oporo ọcha okpukpu abụọ ma na-abawanye uru nke carp site na 155.1%;
Nri na-arụ ọrụ: mmiri mmiri na-egbochi glycation, jikọtara ya na njirimara antioxidant nke bilirubin na-egbu oge ịka nká anụ ahụ.
●Nnweta NEWGREEN BilirubinNtụ ntụ
Oge nzipu: Jun-09-2025
