Andrographis Paniculata Extract: Ngwakọta ahịhịa na-egbochi nje na-egbu egbu na nke siri ike.

●Gịnị bụ Andrographis Paniculata wepụ?

Andrographis paniculata, nke a makwaara dị ka "obi ụtọ otu oge" na "ahịhịa ilu", bụ ahịhịa ahịhịa kwa afọ nke ezinụlọ Acanthaceae. O sitere na South Asia dị ka India na Sri Lanka, ma ugbu a na-ekesa n'ebe nile na iru mmiri na ebe ọkụ dị ka Guangdong na Fujian na China. Osisi ahụ dum na-atọ ụtọ nke ukwuu, ya na azuokokoosisi square, akwụkwọ ndị na-abụghị, yana oge okooko nke August-September. Ọgwụ ndị China ọdịnala na-eji mmetụta ya na-ekpochapụ okpomọkụ na nsị, ime ka ọbara dị jụụ na ibelata ọzịza iji gwọọ oyi, ahụ ọkụ, ọnyụnyụ ọbara, ọnya na ata agwọ. Industrylọ ọrụ ọgbara ọhụrụ na-ewepụta ihe ndị na-arụ ọrụ site na ị ga-ahapụ site na mmịpụta CO₂ dị egwu na teknụzụ bio-enzymatic hydrolysis iji mee ntụ ntụ nwere ọdịnaya andrographolide nke 8%-98%, na-akwalite nkwalite ya site na ọgwụ ahịhịa ndị mmadụ gaa na akụrụngwa mba ụwa.

Isi arụ ọrụ Efrata nkeAndrographis Paniculata Extractsbụ ogige lactone diterpenoid, na-aza 2%-5% 24, ọkachasị gụnyere:

1.  Andrographolide:molecular usoro C₂₀H₃₀O₅, na-aza 30%-50%, bụ isi ihe na-arụ ọrụ maka antibacterial na mgbochi mkpali.
2.  Dehydroandrographolide:molecular usoro C₂₀H₂₈O₄, agbaze ebe 204℃, na ịrịba mgbochi tumor ọrụ.
3. 14-Deoxyandrographolide:Usoro molecular C₂₀H₃₀O, nwere mmetụta pụtara ìhè megide leptospirosis.
4. Neoandrographolide:molekụla usoro C₂₆H₄₀O, ezigbo mmiri solubility, adabara ọnụ preparations.

Na mgbakwunye, flavonoids, acid phenolic na mmanụ na-agbanwe agbanwe na-akwalite ọrụ antioxidant na immunomodulatory.

●Gịnị bụ uru nke Andrographis Paniculata wepụ?

1. Immunomodulation na mgbochi ọrịa

Antibacterial na antiviral: Andrographolide nwere ihe mgbochi ihe karịrị 90% na Staphylococcus aureus na Shigella dysenteriae, yana ịdị irè ya n'ịgwọ ọrịa ọnyụnyụ ọbara dị ka chloramphenicol. Mwepu mmiri ya nwere ike ibelata ọrịa influenza site na 30% ma belata oge oyi site na 50%.

Immunoenhancement: Site na ịgbalite macrophages na T lymphocytes, ọ nwere ike ịbawanye ọkwa nke CD4⁺ lymphocytes na ndị ọrịa HIV (data ụlọ ọgwụ: 405→501/mm³, p=0.002).

2. Mgbochi tumor na mgbochi Angiogenesis

Mgbochi mgbochi kpọmkwem: Dehydroandrographolide nwere ike igbochi uto nke W256 transplanted etuto ma gbochie mgbasa mkpụrụ ndụ kansa n'ụzọ dabere na dose.

Anti-angiogenesis: Andrographolide na-egbochi angiogenesis tumor site na ibelata okwu VEGFR2 na igbochi ụzọ akara ERK/p38, yana IC₅₀ nke 100-200μM.

3. Metabolism na Nchekwa akụkụ

Nchedo imeju na mbelata lipid: Andrographolide na-edobe ọkwa glutathione ma na-ebelata malondialdehyde (MDA) na ụdị mmerụ ahụ nke carbon tetrachloride site na 40%, nke dị mma karịa silymarin.

Nchedo obi obi: Na-ahazi nguzozi nitric oxide/endothelin, na-egbu oge atherosclerosis, ma na-ebelata ọkwa lipid ọbara na oke bekee nnwale.

4. Anti-inflammatory and Antioxidant

Ngwunye mmiri nke azuokokoosisi nwere ikike kachasị ike iji kpochapụ free radicals (IC₅₀ = 4.42μg / mL), nke bụ oge 4 dị irè karịa antioxidants sịntetik ma dị mma maka ọrịa na-adịghị ala ala.

●Kedu ihe bụ ngwa nkeAndrographis Paniculata wepụ ?

1. Ọgwụ na Clinical Ọgwụgwọ

Ọgwụ mgbochi ọrịa: ejiri ya maka ọnyụnyụ ọnyụnyụ nje, ntụtụ oyibo na nkwadebe ọnụ maka pharyngitis, yana ọnụego ọgwụgwọ ụlọ ọgwụ karịrị 85%.

Ọgwụ mgbochi tumor: Andrographolide derivative "Andrographine" abanyela ule ụlọ ọgwụ nke Abụọ maka ọrịa leukemia na etuto siri ike.

Nlekọta ọrịa na-adịghị ala ala: ọgwụgwọ adjuvant nke retinopathy ọrịa shuga (0.5-2mg / kg / ụbọchị) na ọrịa ogbu na nkwonkwo (1-3mg / kg / ụbọchị).

2. Azụ anụ na-azụ ụmụ anụmanụ

Ọgwụ nje ndị ọzọ: Compound Andrographis paniculata feed additives na-ebelata ọnụ ọgụgụ afọ ọsịsa nke piglets ma na-abawanye ọnụego ndụ nke broilers; na-agbakwunye 4% wepụ na nri carp, ọnụ ọgụgụ uru dị arọ na-erute 155.1%, na ọnụego ntụgharị nri na-eme ka ọ bụrụ 1.11.

Mgbochi na njikwa ọrịa: Andrographis paniculata injection na-agwọ ọrịa oyi baa na enteritis, yana ọgwụgwọ ọgwụgwọ nke 90% na ọnụ ọgụgụ ọnwụ nke 10%.

3. Health Food And Daily Chemicals

Nri na-arụ ọrụ: Andrographis paniculatawepụA na-ewepụta capsules (200mg kwa ụbọchị) n'ahịa ndị Europe na America maka usoro mgbochi na mgbochi oyi.

Ngwaahịa na-ahụ maka akpụkpọ ahụ: Tinye na mkpa mgbochi mkpali yana ihe mkpuchi anwụ iji belata mmebi UV na ọbara ọbara nke akpụkpọ ahụ nwere mmetụta.

4. Ọganihu Na-apụta n'ubi

Ọgwụ mgbochi angiogenic: Mmepe nke nkwadebe ezubere iche maka etuto ahụ na retinopathy na-arịa ọrịa mamịrị abụrụla ntụzịaka bụ isi nke bayoloji sịntetik.

Ahụike anụ ụlọ: Mgbochi mgbochi na ihe mgbakwunye immunomodulatory maka nkịta na nwamba ka ewepụtara n'ahịa North America, yana ọnụego uto kwa afọ nke 35%.

●Nnweta NEWGREENAndrographis Paniculata wepụNtụ ntụ