Sodium 3-Hydroxybutyrate: Cov txiaj ntsig, kev siv thiab ntau dua

●Dab tsi yog Sodium 3-Hydroxybutyrate ?

Sodium 3-hydroxybutyrate (sodium β-hydroxybutyrate, BHB-Na) yog cov khoom tseem ceeb ntawm tib neeg ketone lub cev metabolism. Nws tshwm sim nyob rau hauv cov ntshav thiab zis, tshwj xeeb tshaj yog nyob rau hauv lub xeev ntawm kev tshaib kev nqhis los yog tsawg carbohydrate. Kev npaj ib txwm muaj raws li hydrolysis ntawm 3-hydroxybutyric acid esters (methyl ester / ethyl ester) thiab sodium hydroxide, tab sis nws yuav tsum tau organic solvent recrystallization, uas ua rau cov txheej txheem nyuaj, yooj yim nqus noo noo thiab agglomeration ntawm cov khoom, thiab cov kuab tshuaj residual yuav cuam tshuam rau kev nyab xeeb ntawm kev siv kho mob.

Tam sim no, qee lub tuam txhab tau ua tiav hauv cov txheej txheem tshiab: cov impurities ntawm crotonic acid tswj qis dua 16ppm los ntawm methanol-acetone fractional crystallization txoj kev, thiab purity yog nce mus rau 99.5%, uas ua tau raws li tus qauv txhaj tshuaj;

Ib-kauj ruam crystallization tshuab ntawm cov tshuaj tsuag kom qhuav siv 160 ℃ cua kub ncaj qha hloov cov tshuaj tiv thaiv cov kua rau hauv spherical microcrystals, nrog cov khoom tawm los ntawm ntau tshaj 95%. X-ray diffraction spectrum qhia tau hais tias 17 tus yam ntxwv peaks (2θ = 6.1 °, 26.0 °, thiab lwm yam), thiab kev ruaj ntseg ntawm cov qauv siv lead ua yog 3 npaug siab dua li cov txheej txheem ib txwm siv, uas daws cov teeb meem nqus dej kom tiav.

●Dab tsi yog CovCov txiaj ntsigNtawm Sodium 3-Hydroxybutyrate ?

Raws li "super roj molecule", sodium 3-hydroxybutyrate ncaj qha muab lub zog los ntawm cov hlab ntsha-hlwb barrier, thiab nws cov txheej txheem physiological tau tshawb fawb tob hauv xyoo tas los no:

Txoj Cai Metabolic:Hauv cov qauv ntshav qab zib, nws txhim kho cov tshuaj insulin. Ib koob tshuaj ib zaug (0.2 mg / kg) tuaj yeem ua rau lub siab glycogen synthesis ntawm 40%;

Neuroprotection:Cov kev tshawb fawb tau pom tias nws cov derivative 3-hydroxybutyrate methyl ester tuaj yeem qhib L-hom calcium channels, nce calcium ion concentration hauv glial hlwb los ntawm 50%, thiab inhibit cell apoptosis los ntawm 35%, muab txoj hauv kev tshiab rau kev kho mob Alzheimer's disease;

Anti-Inflammatory Thiab Antioxidant:Los ntawm kev txo cov lipid peroxides thiab reactive oxygen hom (ROS), nws txo cov leeg mob tom qab kev tawm dag zog, thiab cov neeg ncaws pob kev ua tau zoo ntawm kev ua tau zoo los ntawm 22% tom qab ntxiv.

●Dab tsi yog CovDaim ntawv thovNtawmSodium 3-Hydroxybutyrate ?

1. Kev Lag Luam Kev Noj Qab Haus Huv: Tus Cwj Pwm ntawm Ketogenic Economy

Kev tswj qhov hnyav: raws li cov khoom xyaw tseem ceeb ntawm cov tshuaj ketogenic, nws ua rau lub siab ua haujlwm ketogenic.

Khoom noj khoom haus kev ua si: dej haus electrolyteSodium 3-Hydroxybutyratecompounded nrog branched-chain amino acids tuaj yeem tswj cov ntshav ketone siab tshaj 4mM tom qab kev tawm dag zog thiab txo cov leeg nqaij rov qab los ntawm 30%.

2. Kev Kho Mob Field: Kev Cia Siab Tshiab Rau Cov Kab Mob Neurodegenerative

Adjuvant kev kho mob ntawm qaug dab peg: ua ke nrog anticonvulsants tuaj yeem txo qhov zaus ntawm qaug dab peg los ntawm 30%, thiab theem III kev kuaj mob tau pib;

Lub hom phiaj kev xa khoom: Cy7 fluorescent sau npe sojntsuam ua tiav hauv vivo tracing, thiab ze-infrared imaging qhia tau hais tias nws yog enriched nyob rau hauv lub hippocampus nyob rau hauv 2 teev, muab ib tug nqa mus rau lub hlwb kev tswj tshuaj.

3. Cov Khoom Siv Kev Tshawb Fawb: Lub Ntsiab Tshuaj lom neeg ua kom tawg dawb paug

Biodegradable plastics: Copolymerized nrog aromatic polyester los ua PHB (poly 3-hydroxybutyrate), nrog lub melting point ntawm 175 ° C thiab oxygen permeability ntawm tsuas yog 1/10 ntawm PET. Nws tuaj yeem degraded tag nrho hauv cov av anaerobic hauv 60 hnub. Guangdong Yuanda New Materials Co., Ltd. tau ua tiav qib kev lag luam loj;

Disintegrating ua liaj ua teb zaj duab xis: PE mulch nrog 5% sodium 3-hydroxybutyrate ntxiv, uas poob nws cov cuab yeej cuab tam tom qab siv, thiab tsis muaj microplastic residues tom qab composting.

●NEWGREEN Supply High QualitySodium 3-Hydroxybutyrate Hmoov