● Dab tsi yogSclareol ?
Sclareol, tshuaj npe (1R,2R,8aS)-decahydro-1-(3-hydroxy-3-methyl-4-pentenyl)-2,5,5,8a-tetramethyl-2-naphthol, molecular formula C₂₀H₃₆O₂, molecular hnyav 9-308. 515-03-7 ib. Nws yog bicyclic diterpenoid compound, nrog cov tsos ntawm dawb crystalline hmoov, melting point 95-105 ℃, boiling point 398.3 ℃, insoluble nyob rau hauv dej, thiab yooj yim soluble nyob rau hauv organic solvents. Nws cov yam ntxwv tseem ceeb yog tias nws muaj lub ntsej muag ntev ntev zoo ib yam li ambergris, nrog cov ntxhiab tsw tsw thiab muaj zog diffusion, ua rau nws zoo tagnrho raw khoom rau high-end perfumes.
Lub ntuj tsim yog cov paj thiab cov stems thiab nplooj ntawm Lamiaceae cog Salvia Sclarea L., uas yog cultivated rau ib tug loj teev nyob rau hauv high-altitude mountainous cheeb tsam xws li sab qaum teb Shaanxi thiab Honghe, Yunnan, Tuam Tshoj. Vim qhov kub thiab txias sib txawv ntawm nruab hnub thiab hmo ntuj thiab cov av noo tsim nyog, clarysol nyob rau hauv cov chaw tsim khoom yog siab purity thiab ntshiab aroma.
Muaj ntau ntau txoj hauv kev rau kev sib xyaw sclareol:
1. Tshuaj synthesis
Feem ntau,sclareolextract yog siv los ua raw khoom rau extraction thiab purification. Cov sclareol residue tom qab cov roj rho tawm yog yaj hauv ethanol, thiab sclareol yog precipitated nyob rau hauv daim ntawv ntawm cov koob dawb tom qab uas tsis kub-kub freezing, pom, activated carbon kho, dilution thiab lwm yam kauj ruam. Tom qab centrifugal lub cev qhuav dej, lub tshuab nqus tsev ziab, crushing thiab tshuaj ntsuam, sclareol nrog cov ntsiab lus cawv siab tuaj yeem tau txais.
2. Biosynthesis
Kev tsim kho ntawm brewer's poov xab cell Hoobkas: Nyob rau hauv txoj kev tshawb no, ob lub synthases TPS thiab LPPs nyob rau hauv sage yog thawj fused rau cov poov xab gene, uas zoo nce zus tau tej cov khoom.sclareol. Tom qab ntawd N-terminus ntawm TPS-LPPS tau txuas nrog rau ib feem ntawm maltose binding protein kom ntxiv dag zog rau kev ruaj ntseg ntawm cov enzyme thiab nce cov txiaj ntsig ntxiv. Tom qab ntawd, pab pawg tshawb fawb tau faib tag nrho cov txheej txheem metabolic rau hauv peb qhov qauv: lub hauv paus metabolic txoj hauv kev rau kev muab acetyl coenzyme A, isoprenoid biosynthesis txoj hauv kev thiab cov txheej txheem tswj hwm kev hloov pauv. Los ntawm kev kho dua tshiab thiab tshem tawm ntawm qee cov noob caj noob ces, lub chassis hom uas tuaj yeem muab tau zoo acetyl-CoA thiab NADPH tau tsim, thiab cov txiaj ntsig ntawm sclareol tau txhim kho ntxiv los ntawm overexpressing qee cov noob. Thaum kawg, qhov cuam tshuam ntawm txhua qhov module ntawm kev sib txuas ntawm sclareol tau txheeb xyuas los ntawm cov txheej txheem metabolic ntawm cov txheej txheem tsim kho, thiab nws tau pom tias peb lub modules muaj kev sib koom ua ke. Fed-batch fermentation tau ua nyob rau hauv co flasks thiab bioreactors, thiab thaum kawg sclareol tau zoo synthesized nyob rau hauv Saccharomyces cerevisiae siv qabzib raws li raw khoom, nrog ib tug yield ntawm 11.4 g / L.
●Dab tsi yog CovCov txiaj ntsigNtawm Sclareol ?
Cov kev tshawb fawb tsis ntev los no tau nthuav tawm ntau qhov kev ua haujlwm lom neeg ntawm sclareol, tshwj xeeb tshaj yog nyob rau hauv cov kab mob hauv nruab nrab paj hlwb:
1. Anti-inflammatory thiab neuroprotective:
inhibits kev ua kom ntau dhau ntawm microglia, txo cov theem ntawm inflammatory yam tseem ceeb TNF-α thiab IL-1β, txo cov kev txav mus los hauv Parkinson tus qauv nas, thiab tiv thaiv dopamine neurons;
Txhim kho kev paub txog kev ua haujlwm hauv Alzheimer tus kab mob qauv. Ib koob tshuaj ntawm 50-200mg / (kg·d) tuaj yeem cuam tshuam kev ua haujlwm ntawm astrocytes hauv lub hlwb thiab txo cov deposition ntawm β-amyloid protein.
2. Anticancer kev ua:
Nws muaj zog cytotoxicity rau cov kab mob qog noj ntshav xws li nas leukemia (P-388) thiab human epidermal carcinoma (KB), thiab inhibits qog proliferation los ntawm inducing apoptosis.
3. Antibacterial thiab antioxidant:
Nws muaj qhov dav dav ntawm inhibition ntawm kev loj hlob ntawm cov kab mob, thiab nws cov kev ua haujlwm antioxidant yog 50 npaug ntawm cov vitamin E, uas yog qhov tsim nyog rau kev hnav khaub ncaws thiab tiv thaiv kev laus ntawm daim tawv nqaij.
●Dab tsi yog CovDaim ntawv thovOf Sclareol ?
1. Flavor thiab tshuaj tsw qab kev lag luam:
Raws li cov khoom siv tseem ceeb rau kev sib txuas ntawm ambergris, nws hloov lub ntuj ambergris los ntawm cov phev whales. Ib qho me me yog siv ncaj qha rau hauv high-end perfumes los muab cov tshuaj tsw qab ua kom ntev thiab muaj txheej txheej.
2. Pharmaceutical research and development:
Alzheimer's kab mob / Parkinson's kab mob tshuaj: qhov ncauj capsules los yog txhaj tshuaj tau nkag mus rau hauv kev tshawb fawb preclinical, tsom rau inhibition ntawm neuroinflamation;
Anti-cancer adjuvant therapy: ua ke nrog cov tshuaj chemotherapy los txhim kho qog cell tua.
3. Tshuaj pleev ib ce thiab khoom noj khoom haus:
Anti-aging ntawm daim tawv nqaij cov khoom: ntxiv 0.5% -2% inhibit photoaging thiab txo ultraviolet erythema;
Natural preservatives: siv rau hauv cov khoom noj oily kom ntev lub neej txee, thiab muaj kev nyab xeeb dua li cov khoom siv hluavtaws.
●NEWGREEN Supply High QualitySclareolHmoov
Post lub sij hawm: Lub Xya hli ntuj-18-2025
