Ivermectin: Ib Tug Tshuaj Tiv Thaiv Kab Mob Tshiab

●Dab tsi yog Ivermectin?

Ivermectin yog ib qho tshuaj tua kab mob semi-synthetic macrolide muab tau los ntawm fermentation thiab purification ntawm Streptomyces avermitilis. Nws feem ntau muaj ob yam: B1a (≥80%) thiab B1b (≤20%). Nws cov mis molecular yog C48H74O14, molecular hnyav yog 875.09, thiab CAS naj npawb yog 70288-86-7.

Hauv xyoo 2015, cov neeg tshawb nrhiav William C. Campbell thiab Satoshi Omura yeej qhov Nobel nqi zog hauv Physiology lossis Tshuaj rau lawv txoj kev koom tes hauv kev tawm tsam dej dig muag thiab tus kab mob ntxhw.

Lub cev thiab tshuaj muaj zog

Khoom: dawb los yog lub teeb daj crystalline hmoov, tsw tsw;

Solubility: yooj yim soluble nyob rau hauv organic solvents xws li methanol, ethanol, acetone, thiab yuav luag insoluble nyob rau hauv dej (solubility yog hais txog 4μg / mL);

Kev ruaj ntseg: tsis yooj yim rau decompose nyob rau hauv chav tsev kub, tab sis yooj yim rau degrade nyob rau hauv lub teeb, yuav tsum tau khaws cia nyob rau hauv ib tug kaw thiab lub teeb-pov thawj ib puag ncig, thiab lub sij hawm ntev cia yuav tsum muaj qhov kub thiab txias ib puag ncig ntawm 2-8 ℃;

●Dab tsi yog CovCov txiaj ntsigNtawm Ivermectin ?

Ivermectin tawm tsam cov kab mob hauv lub paj hlwb precisely los ntawm ob txoj hauv kev:

1. Txhawb kev tso tawm ntawm inhibitory neurotransmitter γ-aminobutyric acid (GABA) los thaiv cov hlab ntsha teeb liab;

2. Qhib glutamate-gated chloride ion channels kom induce hyperpolarization thiab tuag tes tuag taw ntawm parasite cov leeg.

Nws qhov ua tau zoo hauv kev tua cov kab mob nematodes (xws li kab kab kab thiab kab nuv ntses) thiab arthropods (xws li mites, zuam, thiab nab) yog siab li 94% -100%, tab sis nws tsis muaj txiaj ntsig tiv thaiv kab mob thiab kab mob.

●Dab tsi yog CovDaim ntawv thovOf Ivermectin?

1. Veterinary teb (qhov tseeb npaum li cas sib txawv)

nyuj / yaj: 0.2mg / kg (subcutaneous txhaj lossis kev tswj qhov ncauj), tuaj yeem tshem tawm cov kab mob hauv plab, lub ntsws filaria thiab kab mob kab mob ntawm lub cev;

npua: 0.3mg / kg (intramuscular txhaj), tswj tus nqi ntawm roundworms thiab scabies yog ze li ntawm 100%;

Cov dev thiab miv: 6-12μg / kg los tiv thaiv thiab kho cov kab mob plawv, 200μg / kg tua pob ntseg;

Nqaij qaib: 200-300μg / kg (kev tswj qhov ncauj) zoo tiv thaiv qaib roundworms thiab hauv caug mites.

2. Tib neeg kev kho mob

Ivermectinyog ib qho tshuaj tseem ceeb ntawm World Health Organization, feem ntau yog siv rau:

Onchocerciasis (dej qhov muag tsis pom): 0.15-0.2mg / kg ib koob, qhov microfilariae tshem tawm ntau tshaj 90%;

Stregostrongyloidiasis: 0.2mg / kg ib koob;

Ascaris thiab kab mob npaws: 0.05-0.4mg / kg kho lub sijhawm luv.

3. Agricultural tshuaj tua kab

Raws li bio-qhov chaw tshuaj tua kab, nws yog siv los tswj cov nroj tsuag mites, pob zeb diamondback npauj, nplooj miners, thiab lwm yam, thiab muaj cov yam ntxwv qis.

●Kev nyab xeeb thiab kev sib tw

IvermectinNws kuj muaj kev nyab xeeb rau cov tsiaj txhu (nyuaj rau nkag mus rau cov ntshav-hlwb barrier), tab sis tseem muaj contraindications:

Cov tshuaj tiv thaiv tsis zoo: Qee zaus mob taub hau, pob khaus, ntuav nce hauv daim siab enzymes, thiab cov koob tshuaj ntau tuaj yeem ua rau ataxia;

Hom rhiab heev sib txawv: Cov dev yug yaj thiab lwm cov dev yug me nyuam yuav muaj kev mob hnyav heev;

Kev ua me nyuam toxicity: Tsiaj thwmsim qhia tau hais tias cov koob tshuaj ntau muaj kev pheej hmoo ntawm teratogenicity (cleft palate, claw deformity).

Qhov teeb meem thoob ntiaj teb ntawm kev tiv thaiv kab mob parasite yog nce zuj zus. Ib txoj kev tshawb fawb xyoo 2024 tau pom tias kev sib xyaw ntawm ivermectin thiab albendazole tuaj yeem txhim kho kev ua haujlwm ntawm filariasis. Ntau lub tuam txhab tshuaj thoob plaws ntiaj teb tau txhawb nqa kev txhim kho cov khoom siv raw khoom siv tshuab, thiab qhov purity tau mus txog 99%.

● NEWGREEN Supply ZooIvermectinHmoov