Chenodeoxycholic Acid: Cov Khoom Siv Tseem Ceeb Rau Kev Kho Mob Siab, Cov Khoom Noj Ua Si thiab Biomaterials

● Dab tsi yogChenodeoxycholic Acid ?

Chenodeoxycholic Acid (CDCA) yog ib qho ntawm cov khoom tseem ceeb ntawm vertebrate bile, suav txog 30% -40% ntawm tib neeg cov kua tsib acid, thiab nws cov ntsiab lus tseem ceeb hauv cov kua tsib ntawm geese, ducks, npua thiab lwm yam tsiaj.

Txoj kev loj hlob ntawm kev siv thev naus laus zis niaj hnub no:

Supercritical CO₂ extraction: extraction nyob rau hauv qis kub thiab siab siab tej yam kev mob kom tsis txhob muaj organic solvent residues, thiab purity yuav ncav cuag ntau tshaj 98%;

Microbial fermentation txoj kev: siv genetic engineered strains (xws li Escherichia coli) synthesize CDCA, tus nqi yog txo los ntawm 40%, uas yog nyob rau hauv txoj kab nrog tus qauv ntawm ntsuab tshuaj manufacturing;

Txoj kev siv tshuaj lom neeg: siv cov roj cholesterol ua ntej, nws tau txais los ntawm ntau cov kauj ruam cov tshuaj tiv thaiv, haum rau cov khoom lag luam qib siab purity.

Lub cev thiab tshuaj muaj zog ntawmChenodeoxycholic Acid :
Lub npe tshuaj: 3α,7α-dihydroxy-5β-cholanic acid (Chenodeoxycholic Acid)
Cov mis mos molecular: C₂₄H₄₀O₄
Molecular Luj: 392.58 g / mol
Cov tsos mob: dawb crystalline hmoov
Solubility: me ntsis soluble hauv dej, yooj yim soluble hauv ethanol, ether, chloroform
Melting point: 165-168 ℃
Kev ruaj ntseg: rhiab rau lub teeb thiab cua sov, yuav tsum tau txias kom deb ntawm lub teeb (2-8 ℃)

● Cov txiaj ntsig ntawm qhov yog dab tsiChenodeoxycholic Acid ?

1. Dissolution ntawm Cholesterol Gallstones

Mechanism: inhibit siab HMG-CoA reductase, txo cov roj cholesterol synthesis, txhawb cov kua tsib kua qaub, thiab maj mam yaj cov cholesterol gallstones;

Cov ntaub ntawv kho mob: 750mg CDCA ib hnub twg rau 12-24 lub hlis, tus kab mob gallstone tuaj yeem ncav cuag 40% -70%.

2. Kev Kho Mob Ntawm Tus Kheej Biliary Cholangitis (Pbc)

Cov tshuaj thawj zaug: FDA pom zoo Chenodeoxycholic Acid CDCA rau PBC, txhim kho daim siab ua haujlwm ntsuas (ALT / AST txo ntau dua 50%);

Combination therapy: ua keChenodeoxycholic Acidnrog ursodeoxycholic acid (UDCA), qhov ua tau zoo yog txhim kho los ntawm 30%.

3. Kev tswj cov kab mob metabolic

Txo cov ntshav lipids: txo qis cov roj cholesterol tag nrho (TC) thiab cov lipoprotein tsawg (LDL);

Kev tiv thaiv kab mob ntshav qab zib: txhim kho insulin rhiab heev, kev sim tsiaj pom tias cov ntshav qab zib poob li 20%

4. Kev tiv thaiv kab mob thiab tiv thaiv kab mob

inhibit NF-κB txoj hauv kev thiab txo cov kev tso tawm ntawm cov kab mob inflammatory (TNF-α, IL-6);

Cov kev sim tshuaj ntsuam xyuas tau pom tias qhov kev txhim kho ntawm daim siab fibrosis hauv cov neeg mob uas tsis yog-alcoholic fatty siab kab mob (NAFLD) ntau dua 60%.

● Dab tsi yog Daim Ntawv Thov NtawmChenodeoxycholic Acid ?

1. Kev Kho Mob Field

Gallstone kho: CDCA ntsiav tshuaj (250mg / ntsiav tshuaj), koob tshuaj txhua hnub 10-15mg / kg;

PBC kev kho mob: kev npaj ua ke nrog UDCA (xws li Ursofalk®), thoob ntiaj teb kev muag khoom txhua xyoo tshaj US $ 500 lab;

Kev tshawb fawb los tiv thaiv qog: inhibiting daim siab mob qog noj ntshav cell proliferation los ntawm regulating FXR receptors, nkag mus rau theem II soj ntsuam kuaj.

2. Khoom noj khoom haus thiab khoom noj qab haus huv

Cov ntsiav tshuaj tiv thaiv daim siab: cov mis nyuj sib xyaw (CDCA + silymarin), txo cov cawv ua rau lub siab;

Lipid-lowering capsules: synergistic nrog liab poov xab nplej extract los tswj cov ntshav lipid metabolism.

3. Tsiaj Husbandry Thiab Aquaculture

Pub additives: txhim kho tsiaj txhu thiab nqaij qaib rog metabolism, txo cov rog plab;

Ntses noj qab haus huv: ntxiv 0.1%chenodeoxycholic acidtxhawm rau txhim kho cov kab mob carp tiv thaiv thiab nce kev ciaj sia los ntawm 15%.

4. Tshuaj pleev ib ce thiab kho tus kheej

Anti-inflammatory essence: 0.5% -1% ntxiv, txhim kho pob txuv thiab tawv nqaij rhiab heev;

Kev saib xyuas tawv taub hau: inhibit Malassezia thiab txo cov kab mob dandruff.

Los ntawm cov kua tsib ib txwm rho tawm mus rau microbial synthesis, chenodeoxycholic acid tab tom hloov los ntawm "natural ingredient" mus rau "precision tshuaj". Nrog rau kev tshawb fawb tob zuj zus ntawm cov kab mob metabolic thiab tiv thaiv qog, CDCA tuaj yeem dhau los ua cov khoom siv tseem ceeb rau kev kho kab mob siab, khoom noj khoom haus thiab cov khoom siv biomaterials, ua rau lub zog tshiab ntawm 100 billion kev lag luam kev noj qab haus huv.

● NEWGREEN SupplyChenodeoxycholic AcidHmoov