●Dab tsi yog Bilirubin?
Bilirubin yog ib yam khoom ntawm decomposition ntawm cov qe ntshav liab laus. Kwv yees li 2 lab cov qe ntshav liab disintegrate nyob rau hauv tus po txhua hnub. Cov hemoglobin tso tawm yog enzymatically hloov mus rau hauv cov roj-soluble indirect bilirubin, uas tom qab ntawd hloov mus rau hauv dej-soluble ncaj qha bilirubin los ntawm lub siab thiab thaum kawg tawm mus rau hauv txoj hnyuv los ntawm cov kua tsib. Ib qho kev txawv txav hauv cov kab mob metabolic no (xws li hemolysis, lub siab puas tsuaj los yog cov kab mob hauv lub cev) tuaj yeem ua rau bilirubin tsub zuj zuj thiab ua rau daj ntseg.
Cov kev tshawb fawb zaum kawg pom tau tias thaum cov bilirubin concentration yog≥17.05 Nwsμmol / L, kev koom tes ntawm ntshav qab zib thiab mob stroke tuaj yeem raug thaiv, thiab kev pheej hmoo ntawm mob stroke hauv cov txiv neej cov neeg mob ntshav qab zib yog txo los ntawm 2.67 npaug. Lub tshuab yog txhawm rau tiv thaiv kev ua haujlwm siab C-reactive protein thiab lub cev tiv thaiv kab mob, muab cov brakes rau "mob cua daj cua dub".
Bilirubin yog muab rho tawm los ntawm npua thiab shark siab, nyuj gallbladder thiab hlwb hlwb. Peb tau ua tiav kev ua tiav los ntawm kev siv thev naus laus zis:
Supercritical CO₂ rho tawm: khaws cov khoom xyaw tseem ceeb nyob rau hauv ib puag ncig uas tsis muaj qhov kub thiab txias, tsis txhob muaj cov kuab tshuaj residue, thiab ua kom purity ntau dua 98%;
Biological enzymatic hydrolysis txheej txheem: kev hloov pauv ntawm bilirubin glycosides rau hauv aglycones nquag, nce bioavailability los ntawm 50%.
●Dab tsi yog cov txiaj ntsig ntawmBilirubin ?
1. Antioxidant tiv thaiv
Bilirubin yog ib qho tseem ceeb endogenous antioxidant nyob rau hauv lub cev, uas yuav ua tau zoo neutralize dawb radicals (xws li superoxide thiab hydrogen peroxide) thiab txo qhov kev puas tsuaj ntawm oxidative kev nyuaj siab rau cell membranes, proteins thiab DNA. Cov kev tshawb fawb pom tau hais tias tsis tshua muaj siab ntawm bilirubin tuaj yeem txhim kho lub cell tiv thaiv kev puas tsuaj oxidative los ntawm kev ua kom muaj cov kab mob antioxidant (xws li Nrf2 txoj hauv kev), thiab tej zaum yuav txo tau txoj kev pheej hmoo ntawm atherosclerosis thiab neurodegenerative kab mob.
2. Immunomodulatory muaj nuj nqi
Bilirubintuaj yeem tswj hwm lub cev tiv thaiv kab mob los ntawm inhibiting qhov tso tawm ntawm cov kab mob inflammatory (xws li TNF-α thiab IL-6). Nws tuaj yeem txo qhov kev puas tsuaj rau cov ntaub so ntswg los ntawm kev mob ntau dhau thaum tswj hwm qhov sib npaug ntawm lub cev. Piv txwv li, me ntsis siab bilirubin nyob rau hauv lub cev nqaij daim tawv jaundice ntawm cov me nyuam mos yuav pab txo tau txoj kev pheej hmoo ntawm kis kab mob los ntawm no mechanism. Txawm li cas los xij, ntau dhau tuaj yeem cuam tshuam kev ua haujlwm ntawm lub cev tiv thaiv kab mob thiab ua rau muaj kev cuam tshuam rau kev kis kab mob.
3. Cell thiab neuroprotection
Bilirubin muaj kev tiv thaiv tshwj xeeb ntawm lub paj hlwb. Nws tuaj yeem hla cov hlab ntsha-hlwb thaiv thiab tiv thaiv cov neurons los ntawm ischemia lossis degenerative lesions los ntawm inhibiting glutamate excitotoxicity thiab txo oxidative puas tsuaj. Tsis tas li ntawd, bilirubin tuaj yeem txo qhov kev puas tsuaj ntawm daim siab hlwb, cov hlwb myocardial, thiab lwm yam nyob rau hauv hypoxia los yog toxins, thiab tswj lub cev ua haujlwm.
4. Txhawb cov metabolism thiab lub voj voog tawm
Cov txheej txheem metabolic ntawmbilirubinyog qhov txuas tseem ceeb hauv kev rov ua dua ntawm hemoglobin hauv lub cev. Tom qab hemoglobin hauv cov qe ntshav liab uas muaj hnub nyoog yog decomposed rau hauv bilirubin, nws yuav tsum tau ua ke los ntawm daim siab thiab tawm mus rau hauv txoj hnyuv nrog cov kua tsib. Cov kab mob plab hnyuv hloov nws mus rau hauv urobilinogen, ib feem ntawm cov uas yog reabsorbed (enterohepatic ncig), thiab tus so yog excreted nrog quav. Lub voj voog no tsis tsuas yog pab tshem tawm cov khoom pov tseg hauv metabolic, tab sis kuj cuam tshuam nrog plab hnyuv muaj feem cuam tshuam rau tag nrho cov metabolic tshuav.
5. Kev puas tsuaj ntawm qib txawv txav
Ntau dhau bilirubin: Nws tuaj yeem ua rau daj ntseg (daj ntawm daim tawv nqaij thiab sclera), uas yog tshwm sim hauv kab mob siab, kab mob biliary los yog kab mob hemolytic. Thaum pub dawb bilirubin siab dhau lawm, nws tuaj yeem dhau los ntawm cov hlab ntsha-hlwb thiab ua rau cov menyuam mos liab kernicterus (lub hlwb puas).
Tsis tshua muaj bilirubin: Cov kev tshawb fawb tsis ntev los no tau pom tias qhov nce me me hauv bilirubin tuaj yeem muaj kev tiv thaiv, thaum qib qis dhau yuav cuam tshuam nrog kev pheej hmoo ntawm cov kab mob plawv thiab kab mob autoimmune, tab sis cov txheej txheem tshwj xeeb tseem yuav tsum tau kawm.
●Dab tsi yog Daim Ntawv Thov Kev Kho Mob Expansion Ntawm Bilirubin ?
1. Cov khoom siv tshuaj tseem ceeb
Bilirubin yog cov khoom tseem ceeb ntawm cov khoom siv dag zog thiab siv ntau tshaj 130 cov tshuaj, xws li cov hlab plawv thiab cerebrovascular tshuaj (85% muaj txiaj ntsig zoo hauv kev txo cov kab mob hauv lub plawv) thiab kev npaj kev noj qab haus huv.
2. Nano npaj (BRNPs)
Los ntawm nanocarrier thev naus laus zis, kev ua tau zoo thiab lub hom phiaj ntawm bilirubin tau txhim kho zoo heev:
Mob plab rwj: chitosan-bilirubin (CS-BR), inhibits qhov tso tawm ntawm cov kab mob inflammatory thiab txhawb nqa mucosal regeneration.
Lub siab uas tsis yog-alcoholic fatty siab: polyethylene glycol-bilirubin (PEG-BR), txo lub siab rog 30%, thiab txo triglycerides los ntawm 40%.
Psoriasis: hydrogel-bilirubin, txhim kho cov kab mob ntawm daim tawv nqaij, tsis muaj cov kab mob toxicity ntawm corticosteroids
Stroke: TRPM2 channel inhibitor A23, blocks bilirubin neurotoxicity thiab txo qhov me me ntawm infarct.
Lwm daim ntawv thov ntawm bilirubin: tsiaj txhu, kev tiv thaiv ib puag ncig thiab cov khoom siv
Aquaculture: Ntxiv 4% bilirubin rau pub ua ob npaug rau kev tsim cov cw dawb thiab nce qhov hnyav ntawm carp los ntawm 155.1%;
Khoom noj khoom haus: Anti-glycation qhov ncauj kua, ua ke nrog cov antioxidant zog ntawm bilirubin kom ncua kev laus ntawm daim tawv nqaij.
●NEWGREEN muab khoom BilirubinHmoov
Post lub sij hawm: Jun-09-2025
