Andrographis Paniculata Extract: muaj zog Antibacterial Thiab Anti-Inflammatory Herbal Cov khoom xyaw

●Dab tsi yog Andrographis Paniculata Extract?

Andrographis paniculata, tseem hu ua "kev zoo siab ib zaug" thiab "iab nyom", yog tsob nroj txhua xyoo ntawm tsev neeg Acanthaceae. Nws yog ib txwm nyob rau sab qab teb Asia xws li Is Nrias teb thiab Sri Lanka, thiab tam sim no tau nthuav dav hauv thaj chaw ntub thiab kub xws li Guangdong thiab Fujian hauv Suav teb. Tag nrho cov nroj tsuag saj tsis tshua muaj iab, nrog ib tug square qia, ntxeev nplooj, thiab lub sij hawm flowering ntawm lub yim hli ntuj-September. Cov tshuaj suav tshuaj suav tshuaj siv nws cov teebmeem ntawm kev tshem tawm cov cua sov thiab tshem tawm cov co toxins, ua kom cov ntshav txias thiab txo qhov o los kho mob khaub thuas, ua npaws, mob plab, mob thiab nab tom. Kev lag luam niaj hnub muab cov khoom xyaw nquag los ntawm cov stems thiab nplooj los ntawm supercritical CO₂ extraction thiab bio-enzymatic hydrolysis thev naus laus zis los ua cov hmoov txheej txheem nrog cov ntsiab lus andrographolide ntawm 8% -98%, txhawb nqa nws kev txhim kho los ntawm pej xeem tshuaj ntsuab mus rau thoob ntiaj teb raw cov ntaub ntawv.

Cov khoom xyaw tseem ceeb ntawmAndrographis Paniculata Extractsyog diterpenoid lactone tebchaw, accounting rau 2% -5% 24, feem ntau suav nrog:

1.  Andrographolide:Cov mis mos molecular C₂₀H₃₀O₅, accounting rau 30% -50%, yog lub ntsiab active tshuaj rau tshuaj tua kab mob thiab anti-inflammatory.
2.  Dehydroandrographolide:Cov mis mos molecular C₂₀H₂₈O₄, melting point 204 ℃, nrog rau qhov tseem ceeb los tiv thaiv qog.
3. 14-Deoxyandrographolide:Cov mis mos molecular C₂₀H₃₀O₄, muaj txiaj ntsig zoo tiv thaiv leptospirosis.
4. Neoandrographolide:Cov mis mos molecular C₂₆H₄₀O₈, dej solubility zoo, haum rau kev npaj qhov ncauj.

Tsis tas li ntawd, flavonoids, phenolic acids thiab volatile roj Cheebtsam synergistically txhim khu antioxidant thiab immunomodulatory zog.

●Dab tsi yog Cov txiaj ntsig ntawm Andrographis Paniculata Extract?

1. Immunomodulation Thiab Tiv Thaiv Kab Mob

Tshuaj tua kab mob thiab tshuaj tua kab mob: Andrographolide muaj qhov inhibition ntawm ntau dua 90% ntawm Staphylococcus aureus thiab Shigella dysenteriae, thiab nws cov txiaj ntsig kho mob hauv kev kho mob bacillary dysentery yog piv rau chloramphenicol. Nws cov dej extract tuaj yeem txo qhov tshwm sim ntawm tus mob khaub thuas los ntawm 30% thiab txo cov kev mob khaub thuas los ntawm 50%.

Kev tiv thaiv kab mob: Los ntawm kev ua kom cov macrophages thiab T lymphocytes, nws tuaj yeem nce qib ntawm CD4⁺ lymphocytes hauv cov neeg mob HIV (cov ntaub ntawv kho mob: 405 → 501 / mm³, p = 0.002).

2. Anti-Tumor Thiab Angiogenesis Inhibition

Kev tiv thaiv kab mob ncaj qha: Dehydroandrographolide tuaj yeem cuam tshuam kev loj hlob ntawm W256 cov qog hloov pauv thiab tiv thaiv qog nqaij hlav qog noj ntshav raws li koob tshuaj.

Anti-angiogenesis: Andrographolide blocks qog angiogenesis los ntawm downregulating VEGFR2 qhia thiab inhibiting ERK / p38 signaling txoj kev, nrog ib tug IC₅₀ ntawm 100-200μM.

3. Metabolism thiab kev tiv thaiv lub cev

Kev tiv thaiv daim siab thiab txo qis lipid: Andrographolide tswj cov qib glutathione thiab txo cov malondialdehyde (MDA) hauv cov pa roj carbon tetrachloride daim siab mob qauv los ntawm 40%, uas zoo dua li silymarin.

Kev tiv thaiv kab mob plawv: tswj nitric oxide / endothelin tshuav nyiaj li cas, qeeb atherosclerosis, thiab txo cov ntshav lipid hauv kev sim luav.

4. Anti-Inflammatory Thiab Antioxidant

Cov dej extract ntawm qia muaj lub peev xwm muaj zog tshaj plaws kom tshem tawm cov dawb radicals (IC₅₀ = 4.42μg / mL), uas yog 4 npaug ntau dua li cov tshuaj tua kab mob hluavtaws thiab tsim nyog rau cov kab mob inflammatory.

●Dab tsi yog Cov Ntawv Thov NtawmAndrographis Paniculata Extract ?

1. Tshuaj Thiab Kev Kho Mob

Cov tshuaj tiv thaiv kab mob: siv rau cov kab mob dysentery, kev txhaj tshuaj mob ntsws thiab kev npaj qhov ncauj rau pharyngitis, nrog rau kev kho mob ntawm ntau dua 85%.

Cov tshuaj tiv thaiv qog nqaij hlav: Andrographolide derivative "Andrographine" tau nkag mus rau theem II kev sim tshuaj rau cov qog ntshav qog ntshav thiab cov qog nqaij hlav.

Kev tswj kab mob ntev: kev kho mob ntshav qab zib retinopathy (0.5-2mg / kg / hnub) thiab mob caj dab rheumatoid (1-3mg / kg / hnub).

2. Tsiaj Tsiaj Tsiaj Thiab Tsiaj Tsiaj Tsiaj Tsiaj

Lwm hom tshuaj tua kab mob: Compound Andrographis paniculata pub additives txo qhov mob raws plab ntawm piglets thiab ua rau kom cov ciaj sia taus ntawm broilers; ntxiv 4% extract rau carp pub, qhov hnyav nce mus txog 155.1%, thiab pub hloov pauv tus nqi yog optimized rau 1.11.

Kev tiv thaiv kab mob thiab kev tswj hwm: Kev txhaj tshuaj Andrographis paniculata kho swine pneumonia thiab enteritis, nrog kev kho tus nqi ntawm 90% thiab kev tuag ntawm 10%.

3. Khoom noj khoom haus thiab tshuaj lom neeg txhua hnub

Khoom noj khoom haus: Andrographis paniculatarho tawmcapsules (200mg ib hnub) tau tsim tawm hauv European thiab Asmeskas kev lag luam rau kev tiv thaiv kab mob thiab tiv thaiv khaub thuas.

Cov khoom tu tawv nqaij: Ntxiv rau cov tshuaj tiv thaiv kab mob thiab tshuaj pleev thaiv hnub kom txo tau UV puas thiab liab ntawm daim tawv nqaij rhiab.

4. Kev tawg hauv cov teb uas muaj tshwm sim

Cov tshuaj tiv thaiv angiogenic: Kev txhim kho cov phiaj xwm npaj rau cov qog thiab mob ntshav qab zib retinopathy tau dhau los ua cov lus qhia tseem ceeb ntawm cov khoom siv hluavtaws.

Kev kho tsiaj tsiaj: Cov tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob rau cov dev thiab miv tau tsim tawm hauv North American lag luam, nrog rau kev loj hlob txhua xyoo ntawm 35%.

●NEWGREEN muab khoomAndrographis Paniculata ExtractHmoov