ʻO Zinc Pyrithione (ZPT): ʻO kahi Fungicide Nui-Domain

 

●He aha Zinc Pyrithione?

ʻO Zinc pyrithione (ZPT) kahi paʻakikī zinc organik me kahi ʻano molekala o C₁₀H₈N₂O₂S₂Zn (ke kaumaha molekala 317.7). ʻO kona inoa mai nā kumu kumu maoli o ka mea kanu Annonaceae Polyalthia nemoralis, akā ua lawe ka ʻoihana hou i ka synthesis kemika e hana ai. I ka makahiki 2024, ua haki ke kaʻina hana patent a Kina i ka bottleneck maʻemaʻe, a ua hoʻomalu ʻia ka waika crotonic haumia ma lalo o 16ppm ma o ka methanol-acetone graded crystallization, a ua hoʻonui ʻia ka maʻemaʻe pharmaceutical grade i 99.5%.

 

Nā waiwai kino a me kemika:

ʻO ke ʻano a me ka hoʻoheheʻe: keʻokeʻo a hiki i ka liʻiliʻi melemele crystalline pauka, aneane hiki ʻole ke hoʻoheheʻe ʻia i ka wai (<0.1g/100mL), hiki ke hoʻoheheʻe ʻia i ka ethanol, hiki i ka solubility i ka polyethylene glycol ke hiki i 2000mg/kg;

Nā hemahema paʻa: ʻoluʻolu i ka māmā a me nā oxidants, hoʻohaʻahaʻa maʻalahi ʻia e ke kukui ultraviolet, koi ʻia ka ʻeke brown; ʻO ka hemahema o ka dissociation ma ka pH <4.5 a i ʻole> 9.5, ʻo ka pH maikaʻi loa he 4.5-9.5;

ʻO ke kumu koʻikoʻi decomposition wela: paʻa no 120 mau hola ma 100 ℃, akā decompose wikiwiki ma luna o 240 ℃;

ʻAʻole kūpono: hoʻoheheʻe ʻia me nā cationic surfactants, chelates a me nā discolors me nā ion hao / keleawe (hiki i ka 1ppm ke hoʻololi i ka hua melemele).

 

●He aha kaNā pōmaikaʻiNo Zinc Pyrithione ?

Loaʻa iā ZPT ka sterilization ākea ākea (kūpono i nā ʻano microorganisms 32) ma o kahi ʻano hoʻololi ion kūʻokoʻa, ʻoi aku hoʻi no Malassezia, ka mea hewa o ka dandruff, me ka MIC haʻahaʻa e like me 8ppm:

 

1. Ion Gradient luku

I loko o kahi kaiapuni ʻakika, hoʻokomo ʻia ka H⁺ i loko o ka bacteria a ʻo K⁺ ka mea i hoʻopuka ʻia, a ma kahi ʻano alkaline, hoʻololi ʻia ʻo Na⁺/Mg²⁺, kahi e hoʻopau ai i ka ʻōnaehana lawe meaʻai microbial;

 

2. Hoʻohaʻahaʻa ʻia ʻo Cell Membrane

Hoʻokomo i loko o ka phospholipid bilayer, hoʻonui i ka membrane permeability a hoʻoulu i ka leakage mea intracellular;

 

3. Kāohi Hana Hana Enzyme

Ke ālai nei i ke kaulahao lawe electron a me ka pale ʻana i nā enzyme koʻikoʻi o ka metabolism ikehu (e like me ATP synthase).

 

Hōʻoia hōʻoia: Ma hope o ka hoʻohana ʻana i ka shampoo i loaʻa ka 1.5%zincpyrithioneno 4 mau pule, ua hoʻemi ʻia ka dandruff e 90%, a ua hoʻemi ʻia ka helu hoʻi o ka seborrheic dermatitis e 60%.

 

 

●He aha kaPalapala noiOf Zinc Pyrithione?

1. Kahua Kemika o kēlā me kēia lā:

Hiki ke hoʻohana ʻia i 70% o ka shampoo anti-dandruff, me ka nui o ka 0.3%-2%;

 

Hiki i kekahi mau mea hoʻonaninani ke kaupalena i ka hoʻohana ʻana i ka zinc pyrithione a pono e hōʻailona ʻia "holoi ma hope o ka hoʻohana ʻana". Hiki iā ʻoe ke hoʻohana i ka huahana piroctone ethanolamine (OCT).

 

2. ʻOihana Anti-Corrosion:

ʻAi-fouling revolution: hui pū ʻia me ka cuprous oxide e kāohi i ka hoʻopili ʻana i ka barnacle a hoʻemi i ka hoʻohana ʻana i ka wahie moku e 12%;

 

3. Mahiai a me na lako.

ʻO ka pale ʻana i nā hua: 0.5% ka mea hoʻopili e pale i ka maʻi a hoʻonui i ka helu germination e 18%;

 

Antibacterial fiber: grafted polyester fabric he antibacterial rate o> 99%.

 

4. Hoʻonui Lapaʻau:

ʻEkolu kumu hoʻāʻo maikaʻi ʻole (ʻaʻohe carcinogenicity/teratogenicity/mutagenicity), hoʻohana ʻia no ka ʻenekene gel a me ka uhi antibacterial o nā mea lapaʻau.

 

●Manaʻo kōkua:

ʻOiai ka ʻawaʻawa o ka wahaof zinc pyrithionehe haʻahaʻa (LD₅₀>1000mg/kg i nā ʻiole), nā ʻōlelo luhi i nā makahiki i hala iho nei:

 

ʻO ka ʻawaʻawa o ka ʻili: ʻo ka hoʻopili ʻana i ka wā lōʻihi ke kumu o ka maʻi maʻi dermatitis, a ʻo ka pili ʻana i ka ʻili maka hiki ke hoʻoulu i ka conjunctivitis;

 

Contraindications loa:

→ Haʻihaʻi ka ʻili (piʻi ka permeability i 3 mau manawa, ka hopena o ka ʻike ʻōnaehana);

→ Nā wahine hāpai a me nā keiki (ʻaʻole ʻike i ke komo ʻana o ke koko-lolo);

 

Nā pilina lāʻau: E hōʻalo i ka hoʻohana pū ʻana me EDTA (hōʻemi ka chelating zinc ions i ka pono o ka lāʻau).

 

●NEWGREEN Hoʻolako KiʻekiʻeZinc PyrithionePauda