ʻO Sodium 3-Hydroxybutyrate : Nā pōmaikaʻi, nā noi a me nā mea hou aku

●He aha ʻO ka sodium 3-Hydroxybutyrate ?

ʻO ka sodium 3-hydroxybutyrate (sodium β-hydroxybutyrate, BHB-Na) ka mea nui o ke kino ketone metabolism. Loaʻa maoli ia i ke koko a me ka mimi, ʻoi aku ka nui o ka pōloli a i ʻole ka haʻahaʻa haʻahaʻa. Hoʻokumu ʻia ka hoʻomākaukau kuʻuna ma luna o ka hydrolysis o 3-hydroxybutyric acid esters (methyl ester/ethyl ester) a me ka sodium hydroxide, akā pono ia i ka recrystallization solvent organic, kahi e alakaʻi ai i ke kaʻina hana paʻakikī, maʻalahi ka hoʻoheheʻe ʻana o ka wai a me ka agglomeration o nā huahana, a me nā koena koena e hoʻopilikia i ka palekana o nā noi olakino.

I kēia manawa, ua hana kekahi mau hui i nā holomua i ka hana hou: ua hoʻomalu ʻia nā haumia o ka crotonic acid ma lalo o 16ppm e ka methanol-acetone fractional crystallization method, a ua hoʻonui ʻia ka maʻemaʻe i 99.5%, e kū ana i ka maʻamau injection;

Hoʻohana ka ʻenehana crystallization hoʻokahi ʻanuʻu o ka hoʻomaloʻo ʻana i ka ea wela 160 ℃ e hoʻohuli pololei i ka wai hopena i loko o nā microcrystals spherical, me ka hua o ka huahana ma mua o 95%. Hōʻike ka X-ray diffraction spectrum i nā kiʻekiʻe hiʻohiʻona 17 (2θ=6.1 °, 26.0 °, a me nā mea ʻē aʻe), a ʻo ke kūpaʻa o ka hale aniani he 3 mau manawa kiʻekiʻe ma mua o ke kaʻina hana kuʻuna, e hoʻopau loa i ka pilikia o ka hoʻoheheʻe ʻana i ka wai.

●He aha kaNā pōmaikaʻiNo ʻO ka sodium 3-Hydroxybutyrate ?

Ma ke ʻano he "molekele wahie nui", hāʻawi pololei ka sodium 3-hydroxybutyrate i ka ikehu ma o ka pale koko-lolo, a ua ʻimi hohonu ʻia kona ʻano physiological i nā makahiki i hala iho nei:

Hoʻoponopono Metabolic:I loko o kahi hoʻohālike diabetic, hoʻomaikaʻi ia i ka ʻike insulin. Hiki ke hoʻonui i ka nui o ka glycogen synthesis o ka ate i ka 40% i hoʻokahi dosis (0.2 mg / kg);

Neuroprotection:Ua ʻike nā haʻawina e hiki i kāna derivative 3-hydroxybutyrate methyl ester ke hoʻāla i nā kahawai calcium L-type, e hoʻonui i ka nui o ka calcium ion i loko o nā glial cell e 50%, a ke kāohi nei i ka apoptosis cell e 35%, e hāʻawi ana i kahi ala hou no ka mālama ʻana i ka maʻi o Alzheimer;

Anti-Inflammatory a me Antioxidant:Ma ka hōʻemi ʻana i nā lipid peroxides a me nā ʻano oxygen reactive (ROS), hoʻomaha ia i ka ʻāʻī o ka ʻiʻo ma hope o ka hoʻoikaika kino, a hoʻomaikaʻi ʻia ka hana hoʻomanawanui o ka poʻe haʻuki e 22% ma hope o ka hoʻohui ʻana.

●He aha kaPalapala noiNoʻO ka sodium 3-Hydroxybutyrate ?

1. ʻOihana Ola: ʻO ka mea lawe kumu o Ketogenic Economy

Hoʻoponopono paona: ʻo ia ka mea nui o nā mea hoʻohui ketogenic, hoʻoulu ia i ka hana ketogenic o ke ake.

Meaʻai haʻuki: nā mea inu electrolyteʻO ka sodium 3-Hydroxybutyratehui pū ʻia me nā ʻakika amino branched-chain hiki ke mālama i nā ketone koko ma luna o 4mM ma hope o ka hoʻomaʻamaʻa ʻana a hoʻopōkole i ka manawa hoʻihoʻi o ka ʻiʻo e 30%.

2. Kahua Lapaʻau: Manaolana Hou No nā maʻi Neurodegenerative

ʻO ka lāʻau kōkua o ka epilepsy: hui pū ʻia me nā anticonvulsants hiki ke hōʻemi i ka pinepine o ka hopu ʻana ma 30%, a ua hoʻomaka ʻia nā hoʻokolohua lapaʻau o ka pae III;

ʻO ka ʻōnaehana hoʻopuka i manaʻo ʻia: Cy7 fluorescent labeled probes i loaʻa i ka vivo tracing, a hōʻike ʻia ke kiʻi kokoke-infrared i hoʻonui ʻia i ka hippocampus i loko o 2 mau hola, e hāʻawi ana i kahi mea lawe no ka hoʻokele lāʻau lolo.

3. ʻEpekema Materials: The Biological Key To Cracking White Pollution

ʻO nā plastic biodegradable: Copolymerized me ka polyester aromatic e hana i ka PHB (poly 3-hydroxybutyrate), me kahi helu heheʻe o 175°C a me ka oxygen permeability o 1/10 wale nō o PET. Hiki ke hoʻohaʻahaʻa loa i ka lepo anaerobic i nā lā 60. Ua hoʻokō ʻo Guangdong Yuanda New Materials Co., Ltd. i ka hana ʻoihana nui;

Kiʻiʻoniʻoni mahiʻai hoʻokaʻawale: PE mulch me 5% sodium 3-hydroxybutyrate i hoʻohui ʻia, e nalowale ana kona mau waiwai mechanical ma hope o ka hoʻohana ʻana, a ʻaʻohe koena microplastic ma hope o ka hoʻopuehu ʻana.

●NEWGREEN Hoʻolako KiʻekiʻeʻO ka sodium 3-Hydroxybutyrate Pauda