●He aha iaSclareol ?
Sclareol, inoa kemika (1R,2R,8aS) -decahydro-1-(3-hydroxy-3-methyl-4-pentenyl) -2,5,5,8a-tetramethyl-2-naphthol, molecular formula C₂₀H₃₆O₂, molecular paona 308.29-308.29-0. 515-03-7. ʻO ia ka hui bicyclic diterpenoid, me ke ʻano o ka pauka crystalline keʻokeʻo, ka helu heheʻe 95-105 ℃, kahi paila 398.3 ℃, hiki ʻole ke hoʻoheheʻe ʻia i ka wai, a hiki ke hoʻoheheʻe ʻia i loko o nā mea hoʻoheheʻe organik. ʻO kona hiʻohiʻona nui, ʻo ia ka loaʻa ʻana o kahi ʻala lōʻihi e like me ka ambergris, me ka ʻala maikaʻi a me ka hoʻopuehu ikaika ʻana, e lilo ia i mea waiwai kūpono no nā mea ʻala kiʻekiʻe.
ʻO ke kumu kūlohelohe ka nui o ka inflorescence a me nā ʻōpala a me nā lau o ka lāʻau Lamiaceae Salvia Sclarea L., i mahi ʻia ma kahi ākea nui ma nā wahi mauna kiʻekiʻe e like me ke kūkulu ʻākau o Shaanxi a me Honghe, Yunnan, Kina. Ma muli o ka ʻokoʻa nui o ka mahana ma waena o ke ao a me ka pō a me ka haʻahaʻa kūpono, ʻo ka clarysol i kēia mau wahi hana he maʻemaʻe kiʻekiʻe a me ka ʻala maʻemaʻe.
Nui nā ala nui no ka synthesizing sclareol:
1. Hoʻohui kemika
maʻamau,sclareolHoʻohana ʻia ka extract e like me ka mea maka no ka ʻohi a me ka hoʻomaʻemaʻe. Hoʻoheheʻe ʻia ke koena sclareol ma hope o ka lawe ʻana i ka aila i loko o ka ethanol, a ua hoʻoheheʻe ʻia ka sclareol ma ke ʻano o nā nila keʻokeʻo ma hope o ka haʻahaʻa haʻahaʻa haʻahaʻa, kānana, hoʻōla kalapona hoʻōla, dilution a me nā hana ʻē aʻe. Ma hope o ka dehydration centrifugal, maloʻo maloʻo, ʻokiʻoki a me ka nānā ʻana, hiki ke loaʻa ka sclareol me ka nui o ka waiʻona.
2. Biosynthesis
Ke kūkulu ʻia ʻana o kahi hale hana hū o ka brewer.sclareol. A laila ua hoʻopili ʻia ka N-terminus o TPS-LPPS i kahi ʻāpana o ka maltose binding protein e hoʻomaikaʻi hou i ka paʻa o ka enzyme a hoʻonui hou i ka hua. A laila, hoʻokaʻawale ka hui noiʻi i ke ala metabolic holoʻokoʻa i ʻekolu modules: ke ala metabolic waena no ka hoʻolako ʻana i ka acetyl coenzyme A, ke ala isoprenoid biosynthesis a me ka module regulatory factor no ka hoʻololi ʻana o ka ʻōnaehana. Ma muli o ka hoʻihoʻi ʻana a me ka holoi ʻana i kekahi mau genes pili, ua kūkulu ʻia kahi kānana chassis e hiki ai ke hoʻolako pono i ka acetyl-CoA a me NADPH, a ua hoʻomaikaʻi hou ʻia ka hua o ka sclareol ma o ka hoʻonui ʻana i kekahi mau genes. ʻO ka mea hope loa, ua ʻike ʻia ka hopena o kēlā me kēia module i ka synthesis o ka sclareol ma o ka ʻaoʻao metabolic o ke kānana engineered, a ua ʻike ʻia he hopena synergistic nā modula ʻekolu. Hana ʻia ka fermentation Fed-batch i loko o nā ipu lulu a me nā bioreactors, a i ka hopena ua hana ʻia ʻo sclareol i Saccharomyces cerevisiae me ka hoʻohana ʻana i ka glucose ma ke ʻano he kumu, me ka hua o 11.4 g/L.
●He aha kaNā pōmaikaʻiNo Sclareol ?
Ua hōʻike ʻia nā haʻawina hou i ka hana biological multi-dimensional o ka sclareol, ʻoi aku hoʻi i ke kahua o nā maʻi o ka ʻōnaehana nerve waena.
1. Anti-inflammatory a me neuroprotective:
Kāohi i ka hoʻoulu nui ʻana o ka microglia, hoʻemi i nā pae o nā mea inflammatory TNF-α a me IL-1β, hoʻokuʻu i nā pilikia neʻe i nā ʻiole kumu hoʻohālike o Parkinson, a pale i nā neurons dopamine;
Hoʻomaikaʻi i ka hana cognitive i nā hiʻohiʻona maʻi o Alzheimer. Hiki i ka nui o 50-200mg / (kg · d) ke kāohi i ka hoʻoulu ʻana o nā astrocytes i loko o ka lolo a hoʻemi i ka waiho ʻana o ka protein β-amyloid.
2. Ka hana anticancer:
He ikaika kona cytotoxicity i nā laina cell cancer e like me ka leukemia ʻiole (P-388) a me ka carcinoma epidermal kanaka (KB), a ke kāohi nei i ka hoʻonui ʻana o ka maʻi ma ka hoʻoulu ʻana i ka apoptosis.
3. Antibacterial a me ka antioxidant:
Loaʻa iā ia kahi ākea ākea o ka pale ʻana i ka ulu ʻana o ka maʻi bacteria, a ʻo kāna hana antioxidant he 50 mau manawa ma mua o ka huaora E, kūpono ia no nā ʻaʻahu ʻeha a me nā huahana mālama ʻili.
●He aha kaPalapala noiOf Sclareol ?
1. ʻOihana ʻala a ʻala:
Ma ke ʻano he kumu kumu no ka synthesis o ka ambergris, hoʻololi ʻo ia i ka ambergris maoli mai nā kohola sperm e pau ana. Hoʻohana pololei ʻia kahi mea liʻiliʻi i nā mea ʻala kiʻekiʻe e hāʻawi i ka ʻala i ka manaʻo mau loa a hoʻopaʻa ʻia.
2. Ka noiʻi a me ka hoʻomohala lāʻau lapaʻau:
ʻO ka maʻi o Alzheimer/Parkinson's maʻi lāʻau: ua komo nā capsules waha a i ʻole injections i ka noiʻi preclinical, e kuhikuhi ana i ka pale ʻana i ka neuroinflammation;
Anti-cancer adjuvant therapy: hui pū ʻia me nā lāʻau lapaʻau chemotherapy e hoʻomaikaʻi ai i ka pepehi ʻana i nā cell tumor.
3. Mea hoʻonani a me ka meaʻai:
Nā huahana mālama ʻili anti-kahiko: hoʻohui i ka 0.5% -2% e kāohi i ka photoaging a hōʻemi i ka erythema ultraviolet;
Nā mea mālama kūlohelohe: hoʻohana ʻia i nā meaʻai aila e hoʻolōʻihi i ke ola o ka papa, a ʻoi aku ka palekana ma mua o nā huahana synthetic.
●NEWGREEN Hoʻolako KiʻekiʻeSclareolPauda
Ka manawa hoʻouna: Jul-18-2025
