ʻO Chenodeoxycholic Acid: He mea waiwai no ka mālama ʻana i ka maʻi ate, nā meaʻai kūpono a me nā biomaterial.

● He ahaChenodeoxycholic Acid ?

ʻO Chenodeoxycholic Acid (CDCA) kekahi o nā mea nui o ka bile vertebrate, e helu ana no 30% -40% o ka wai bile kanaka, a ʻoi aku ka kiʻekiʻe o kāna ʻike i loko o ka bile o nā geese, ducks, puaʻa a me nā holoholona ʻē aʻe.

Nā holomua i ka ʻenehana unuhi hou:

Supercritical CO₂ extraction: unuhi ma lalo o haʻahaʻa haʻahaʻa a me ke kiʻekiʻe puʻe kūlana e pale aku organic solvent koena, a me ka maemae hiki ke oi aku mamua o 98%;

Microbial fermentation ala: hoʻohana genetically engineered strains (e like me Escherichia coli) e synthesize CDCA, ua ho'ēmiʻia ke kumukūʻai e 40%, i ka laina me ke au o ka 'ōmaʻomaʻo pharmaceutical manufacturing;

ʻO ke kaʻina hana synthesis: me ka hoʻohana ʻana i ka cholesterol ma ke ʻano he precursor, loaʻa ia ma o nā hopena he nui, kūpono no nā huahana lāʻau lapaʻau maʻemaʻe kiʻekiʻe.

Nā waiwai kino a me kemika oChenodeoxycholic Acid :
Ka inoa kemika: 3α,7α-dihydroxy-5β-cholanic acid (Chenodeoxycholic Acid)
Huina molekala: C₂₄H₄₀O₄
Kaumaha Molekala: 392.58 g/mol
ʻAno: ka pauka crystalline keʻokeʻo
Solubility: hiki ke hoʻoheheʻe iki i ka wai, hiki ke hoʻoheheʻe ʻia i ka ethanol, etera, chloroform
Ka helu hehee: 165-168 ℃
Paʻa: ʻoluʻolu i ka mālamalama a me ka wela, pono e hoʻoluʻu ʻia mai ka mālamalama (2-8 ℃)

● He aha nā pōmaikaʻi o kaChenodeoxycholic Acid ?

1. Hoʻopau ʻia ʻo Cholesterol Gallstones

Mechanism: pale i ka ate HMG-CoA reductase, ho'ēmi i ka cholesterol synthesis, hoʻoikaika i ka bile acid huna, a hoʻoheheʻe mālie i ka cholesterol gallstones;

ʻO ka ʻikepili maʻi: 750mg CDCA i kēlā me kēia lā no 12-24 mau mahina, hiki ke piʻi ka nui o ka dissolution gallstone i 40% -70%.

2. Ka Lapaʻau ʻana i ka Cholangitis Biliary Primary (Pbc)

ʻO nā lāʻau lapaʻau mua: Ua ʻae ʻo FDA i ka Chenodeoxycholic Acid CDCA no PBC, hoʻomaikaʻi i nā hōʻailona hana o ka ate (ALT/AST i hoʻemi ʻia ma mua o 50%);

Hoʻohui hui: hui ʻiaChenodeoxycholic Acidme ka ursodeoxycholic acid (UDCA), ua hoʻomaikaʻi ʻia ka maikaʻi e 30%.

3. Hooponopono No na Ma'i Metabolic

Hoʻohaʻahaʻa i nā lipids koko: hoʻohaʻahaʻa i ka serum total cholesterol (TC) a me ka lipoprotein haʻahaʻa haʻahaʻa (LDL);

Anti-diabetes: hoʻomaikaʻi i ka naʻau o ka insulin, hōʻike nā hoʻokolohua holoholona e hāʻule ke kō koko e 20%

4. Ka hooponopono ana i ka ma'i a me ke kino

Kāohi i ke ala NF-κB a hoʻemi i ka hoʻokuʻu ʻana o nā mea inflammatory (TNF-α, IL-6);

Ua hōʻike ʻia nā hoʻokolohua lapaʻau ʻoi aku ka maikaʻi o ka fibrosis ate i nā poʻe maʻi me ka maʻi momona momona ʻole (NAFLD) ma mua o 60%.

● He aha nā noi oChenodeoxycholic Acid ?

1. Kahua Lapaʻau

ʻO ka lāʻau lapaʻau: nā papa CDCA (250mg/papa), ka nui o kēlā me kēia lā 10-15mg/kg;

Hoʻomaʻamaʻa PBC: hoʻomākaukau pū me UDCA (e like me Ursofalk®), ʻoi aku ka nui o nā kūʻai makahiki honua ma mua o US $ 500 miliona;

Ka noiʻi anti-tumor: kaohi ʻana i ka hoʻonui ʻana o ka maʻi maʻi ate ma o ka hoʻoponopono ʻana i nā mea loaʻa FXR, e komo ana i nā hoʻokolohua lapaʻau Phase II.

2. Nā meaʻai kūpono a me nā huahana olakino

ʻO nā papa hoʻomalu o ke ake: hoʻohuihui ʻia (CDCA + silymarin), hōʻemi i ka pōʻino o ka ate;

ʻO nā capsules hoʻohaʻahaʻa i ka lipid: synergistic me ka laiki hū ʻulaʻula e hoʻoponopono i ka metabolism lipid koko.

3. Hanai holoholona a me ka i'a

E hānai i nā mea hoʻohui: hoʻomaikaʻi i ka metabolism momona o nā holoholona a me nā moa, e hoʻemi i ka momona o ka ʻōpū;

Ola iʻa: hoʻonui i ka 0.1%chenodeoxycholic acide hoʻoikaika i ka pale ʻana i ka maʻi carp a hoʻonui i ka helu ola e 15%.

4. Mea hoʻonani a me ka mālama pilikino

ʻO ke kumu anti-inflammatory: 0.5% -1% hoʻohui, hoʻomaikaʻi i ka ʻili a me ka ʻili;

Ka mālama ʻana i ke poʻo: pale i ka Malassezia a hoʻemi i ka hanauna dandruff.

Mai ka lawe ʻana i ka bile kuʻuna a hiki i ka microbial synthesis, ke hele nei ka chenodeoxycholic acid i kahi hoʻololi mai kahi "mea kūlohelohe" i kahi "lāʻau lapaʻau pololei". Me ka hohonu o ka noiʻi ʻana i nā maʻi metabolic a me ka anti-tumor, hiki i ka CDCA ke lilo i kumu kumu no ka mālama ʻana i nā maʻi ate, nā meaʻai hana a me nā biomaterials, e alakaʻi ana i kahi nalu hou o ka ʻoihana olakino 100 billion.

● Hoʻolako hou ʻo NEWGREENChenodeoxycholic AcidPauda