●He aha ka Bilirubin?
ʻO ka Bilirubin kahi huahana o ka decomposition o nā ʻeleʻele ʻulaʻula kahiko. Ma kahi o 2 miliona mau ʻulaʻula e hoʻoheheʻe ʻia i loko o ka spleen i kēlā me kēia lā. Hoʻololi enzymatically ka hemoglobin i hoʻokuʻu ʻia i bilirubin indirect indirect, a laila hoʻololi ʻia i bilirubin pololei hiki ke hoʻoheheʻe ʻia i ka wai e ke ake a hoʻokuʻu ʻia i loko o ka ʻōpū ma o ka bile. ʻO nā mea ʻino i loko o kēia kaulahao metabolic (e like me ka hemolysis, ka pōʻino o ka ate a i ʻole ka ʻāʻī ʻana o ka bile duct) hiki ke alakaʻi i ka hōʻiliʻili bilirubin a hoʻoulu i ka jaundice.
Ua ʻike ʻia ka noiʻi hou loa i ka wā e piʻi ai ka bilirubin≥17.05μmol/L, hiki ke hoʻopaʻa ʻia ka hui ma waena o ka maʻi diabetes a me ka hahau ʻana, a ua hoʻemi ʻia ka pilikia o ka hahau ʻana i nā maʻi maʻi maʻi kāne kāne i 2.67 manawa. ʻO ka mīkini ka mea e pale ai i ka protein C-reactive kiʻekiʻe a me ka ʻōnaehana immune immune index index, e kau ana i nā kaʻa ma ka "ʻino inflammatory".
Lawe ʻia ka Bilirubin mai ke ake o ka puaʻa a me ka manō, ka ʻōpū pipi a me ka lolo. Ua loaʻa iā mākou nā holomua ma o ka ʻenehana ʻenehana:
Supercritical CO₂ extraction: hoʻopaʻa i nā mea hana ma lalo o ka haʻahaʻa haʻahaʻa haʻahaʻa, pale i ke koena solvent, a hoʻonui i ka maʻemaʻe ma mua o 98%;
ʻO ke kaʻina hana hydrolysis biological enzymatic: ka huli ʻana o ka bilirubin glycosides i loko o nā aglycones ikaika, e hoʻonui ana i ka bioavailability e 50%.
●He aha nā pōmaikaʻi o kaBilirubin ?
1. Palena antioxidant
ʻO Bilirubin kahi antioxidant endogenous nui i loko o ke kino, hiki ke hoʻopau maikaʻi i nā radical manuahi (e like me ka superoxide a me ka hydrogen peroxide) a hoʻemi i ka pōʻino o ke koʻikoʻi oxidative i nā membrane cell, protein a me DNA. Ua hōʻike nā haʻawina e hiki i nā haʻahaʻa haʻahaʻa o ka bilirubin ke hoʻoikaika i ka pale o ke kelepona i ka pōʻino oxidative ma o ka hoʻoulu ʻana i nā ala hōʻailona antioxidant (e like me ke ala Nrf2), a hiki ke hōʻemi i ka pilikia o ka atherosclerosis a me nā maʻi neurodegenerative.
2. Ka hana immunomodulatory
Bilirubinhiki ke hoʻoponopono i nā pane palekana ma ke kāohiʻana i ka hoʻokuʻuʻana o nā mea inflammatory (e like me TNF-α a me IL-6). Hiki iā ia ke hōʻemi i ka pōʻino o nā ʻiʻo i hoʻokumu ʻia e ka ʻeha nui ʻoiai e mālama ana i ke koena o ka ʻōnaehana pale. No ka laʻana, hiki i ka hoʻonui haʻahaʻa bilirubin i ka jaundice physiological o nā pēpē hou ke kōkua i ka hōʻemi ʻana i ka pilikia o ka maʻi ma o kēia hana. Eia nō naʻe, hiki i ka nui o ka hoʻopaʻa ʻana ke kāohi i ka hana o nā cell immune a hoʻonui i ka maʻi i ka maʻi.
3. Pūnaewele a me ka neuroprotection
He hopena pale kūikawā ko Bilirubin i ka ʻōnaehana nerve. Hiki iā ia ke hele i ka pale koko-lolo a pale i nā neurons mai ischemia a i ʻole degenerative lesions ma ke kāohi ʻana i ka glutamate excitotoxicity a me ka hōʻemi ʻana i ka pōʻino oxidative. Eia hou, hiki i ka bilirubin ke hoʻemi i ka pōʻino o nā pūnaewele o ke ake, nā pūnaʻi myocardial, a me nā mea ʻē aʻe ma lalo o ka hypoxia a i ʻole nā toxin, a mālama i ka hana o ke kino.
4. Hoʻoikaika i ka metabolism a me ka pōʻai excretion
ʻO ke kaʻina hana metabolic obilirubinHe loulou nui ia i ka hana hou ʻana o ka hemoglobin i loko o ke kino. Ma hope o ka hemo ʻana o ka hemoglobin i loko o ka bilirubin, pono e hui pū ʻia e ke ake a hoʻokuʻu ʻia i loko o ka ʻōpū me ka bile. Hoʻololi ʻia e nā maʻi ʻōpū i loko o ka urobilinogen, kahi hapa o ka reabsorbed (enterohepatic circulation), a hoʻokuʻu ʻia ke koena me nā feces. ʻAʻole kōkua wale kēia pōʻai i ka wehe ʻana i ka ʻōpala metabolic, akā pili pū kekahi me ka flora intestinal e hoʻopilikia i ke koena metabolic holoʻokoʻa.
5. Ka pōʻino o nā pae ʻokoʻa
Ka nui o ka bilirubin: Hiki ke hoʻoulu i ka jaundice (ʻeleʻele o ka ʻili a me ka sclera), ka mea maʻamau i ka maʻi hepaʻa, keakea biliary a i ʻole nā maʻi hemolytic. Ke kiʻekiʻe loa ka bilirubin manuahi, hiki iā ia ke hele i loko o ka pale koko-lolo a hoʻoulu i ka neonatal kernicterus (pōʻino lolo).
ʻO ka haʻahaʻa loa o ka bilirubin: Ua ʻike ʻia nā haʻawina hou he hopena pale ka piʻi liʻiliʻi o ka bilirubin, ʻoiai ʻo ka haʻahaʻa haʻahaʻa e pili pū ana me ka piʻi ʻana o ka maʻi cardiovascular a me ka maʻi autoimmune, akā pono ke aʻo ʻia ka mīkini kikoʻī.
●He aha ka Hoʻonui Lapaʻau Lapaʻau O Bilirubin ?
1. ʻO nā kumu lāʻau lapaʻau kumu
ʻO Bilirubin ka mea nui o ka bezoar artificial a hoʻohana ʻia i nā lāʻau ʻoi aku ma mua o 130, e like me nā lāʻau cardiovascular a me ka cerebrovascular (85% maikaʻi i ka hoʻomaha ʻana i ka maʻi puʻuwai coronary) a me nā hoʻomākaukau hoʻoponopono menopausal.
2. Nā hoʻomākaukau Nano (BRNPs)
Ma o ka ʻenehana nanocarrier, ua hoʻomaikaʻi nui ʻia ka maikaʻi a me ka huli ʻana o bilirubin:
Acute gastric ulcer: chitosan-bilirubin (CS-BR), kaohi i ka huna o na mea inflammatory a paipai i ka mucosal regeneration
ʻO ke akepaʻa momona ʻole: polyethylene glycol-bilirubin (PEG-BR), hoʻemi i ka hōʻiliʻili momona o ka ate ma 30%, a hoʻemi i nā triglycerides e 40%
Psoriasis: hydrogel-bilirubin, hoʻomaikaʻi i nā ʻili ʻili, me ka ʻole o ka ʻona kino o nā corticosteroids
Ka hahau: TRPM2 channel inhibitor A23, poloka i ka bilirubin neurotoxicity a hoemi i ka nui infarct.
Nā noi ʻē aʻe o ka bilirubin: ka mahiʻai holoholona, ka mālama ʻana i ke kaiapuni a me nā huahana hana
Aquaculture: ʻO ka hoʻohui ʻana i ka 4% bilirubin e hānai i pāpālua i ka hana ʻana o ka ʻōpae keʻokeʻo a hoʻonui i ke kaumaha o ka carp ma 155.1%;
Meaʻai hana: Anti-glycation waha wai, hui pū me nā waiwai antioxidant o bilirubin e hoʻopaneʻe i ka ʻelemakule ʻili.
●Hoolako NU HOU BilirubinPauda
Ka manawa hoʻouna: Jun-09-2025
