●He aha ka Berberine?
ʻO Berberine kahi alkaloid maoli i unuhi ʻia mai nā aʻa, nā ʻōpala a me nā ʻili o nā mea kanu like ʻole, e like me Coptis chinensis, Phellodendron amurense a me Berberis vulgaris. ʻO ia ka mea hana nui o Coptis chinensis no ka hopena antibacterial.
ʻO Berberine kahi aniani melemele me ka ʻono ʻawaʻawa. ʻO ka mea ʻawaʻawa nui ma Coptis chinensis ka berberine hydrochloride. He isoquinoline alkaloid kēia i hoʻolaha ʻia i loko o nā mea kanu kūlohelohe. Aia ia ma Coptis chinensis ma ke ʻano o ka hydrochloride (berberine hydrochloride). Ua ʻike nā haʻawina e hiki ke hoʻohana ʻia kēia pūhui no ka mālama ʻana i nā maʻi koko, ka maʻi hepa, nā maʻi cardiovascular, hypertension, nā maʻi maʻi bacterial a me nā maʻi viral, ka maʻi maʻi, ka maʻi Alzheimer a me ka ʻāʻī.
● He aha nā pono olakino o Berberine?
1. Antioxidant
Ma lalo o nā kūlana maʻamau, mālama ke kino o ke kanaka i ke kaulike ma waena o nā antioxidants a me nā prooxidants. ʻO ke koʻikoʻi oxidative he kaʻina hana ʻino i hiki ke lilo i mea koʻikoʻi no ka hōʻino ʻana o ka hale cell, a laila e hoʻoulu ai i nā ʻano maʻi like ʻole e like me ka maʻi cardiovascular, cancer, neurological maʻi a me ka maʻi diabetes. ʻO ka hana nui ʻana o nā ʻano oxygen reactive (ROS), ka mea maʻamau ma o ka hoʻoulu nui ʻana o NADPH e nā cytokines a i ʻole ma o ke kaulahao transport electron mitochondrial a me xanthine oxidase, hiki ke alakaʻi i ke kaumaha oxidative. Ua hōʻike ʻia nā hoʻokolohua ʻo ka berberine metabolites a me ka berberine hōʻike maikaʻi loa i ka hana scavenging -OH, kahi mea like me ka potent antioxidant vitamina C. Hiki i ka lawelawe ʻana o ka berberine i nā ʻiole diabetic ke nānā i ka piʻi ʻana o ka hana SOD (superoxide dismutase) a me ka emi ʻana o nā pae MDA (he marker of lipid peroxidation) pae [1]. Hōʻike ʻia nā hopena hou aʻe e pili pono ana ka hana scavenging o berberine me kāna hana ferrous ion chelating, a ʻo ka hui C-9 hydroxyl o berberine he ʻāpana koʻikoʻi.
2.Ai-ke koko
Ua nui nā hōʻike e pili ana i ka hopena anti-cancer oberberine. Ua hōʻike ʻia nā haʻawina like ʻole i nā makahiki i hala iho nei he koʻikoʻi nui ka berberine i ka mālama ʻana i nā maʻi maʻi maʻi koʻikoʻi e like me ka maʻi maʻi ovarian, ka maʻi maʻi endometrial, ka maʻi maʻi cervical, ka maʻi maʻi umauma, ka maʻi ʻāʻī, ka maʻi ʻaʻai colorectal, ka maʻi maʻi maʻi maʻi, ka maʻi maʻi maʻi, a me ka maʻi prostate [2]. Hiki i ka Berberine ke pale i ka hoʻonui ʻana o nā pūnaʻi tumora ma o ka launa pū ʻana me nā ʻano pahuhopu a me nā mīkini. Hiki iā ia ke hoʻololi i ka hōʻike o nā oncogenes a me nā genes pili i ka carcinogenesis e hoʻokō i ke kumu o ka hoʻoponopono ʻana i ka hana o nā enzymes pili e kāohi ai i ka hoʻonui.
3. Hoʻohaʻahaʻa i nā lipids koko a pale i ka ʻōnaehana cardiovascular
He kuleana koʻikoʻi ʻo Berberine i ka mālama ʻana i nā maʻi cardiovascular a loaʻa i kahi ākea o nā noi. Hoʻokō ʻo Berberine i ke kumu o ka anti-arrhythmia ma o ka hōʻemi ʻana i ka ulu ʻana o ka ventricular premature beats a me ka pale ʻana i ka hanana ventricular tachycardia. ʻO ka lua, ʻo ka dyslipidemia kahi kumu pilikia nui no ka maʻi cardiovascular, i hōʻike ʻia e nā kiʻekiʻe kiʻekiʻe o ka kolamu holoʻokoʻa, triglycerides, a me ka lipoprotein cholesterol haʻahaʻa (LDL), a me ka emi ʻana o ka lipoprotein kiʻekiʻe kiʻekiʻe (HDL), a hiki i ka berberine ke mālama ikaika i ka paʻa o kēia mau hōʻailona. ʻO ka hyperlipidemia lōʻihi kahi kumu nui o ka hoʻokumu ʻana o ka atherosclerotic plaque. Ua hōʻike ʻia e pili ana ka berberine i nā mea loaʻa LDL i nā hepatocytes e hoʻemi i ke kiʻekiʻe o ka cholesterol serum kanaka i nā hepatocytes. ʻAʻole wale kēlā,berberinehe hopena inotropic maikaʻi a ua hoʻohana ʻia no ka mālama ʻana i ka naʻau congestive.
4. Hoʻohaʻahaʻa i ke kō koko a hoʻoponopono i ka endocrine
ʻO ka maʻi diabetes mellitus (DM) kahi maʻi metabolic i hōʻike ʻia e ke kiʻekiʻe o ke kō koko koko (hyperglycemia) ma muli o ka hiki ʻole o nā pūnaʻi B pancreatic ke hoʻohua i ka insulin, a i ʻole ka nalowale ʻana o ka pane ʻana o nā kiko kiko kūpono i ka insulin. Ua ʻike ʻia ka hopena hypoglycemic o berberine i ka makahiki 1980 i ka mālama ʻana i nā maʻi maʻi maʻi me ka maʻi maʻi.
He nui nā haʻawina i hōʻike i kēlāberberinehoʻohaʻahaʻa i ke kō koko ma o nā hana penei:
● Kāohi i ka mitochondrial glucose oxidation a hoʻoulu i ka glycolysis, a laila hoʻonui i ka metabolism glucose;
● Hoʻemi i nā pae ATP ma ke kāohi ʻana i ka hana mitochondrial i loko o ke ake;
● Kāohi i ka hana o DPP 4 (he ubiquitous serine protease), ma laila e hoʻokaʻawale ai i kekahi mau peptides e hana e hoʻonui i ka nui o ka insulin i mua o ka hyperglycemia.
● He hopena maikaʻi ka Berberine i ka hoʻomaikaʻi ʻana i ka insulin resistance a me ka hoʻohana ʻana i ka glucose i loko o nā ʻiʻo ma o ka hoʻohaʻahaʻa ʻana i nā lipids (ʻoi aku ka triglycerides) a me nā pae momona momona ʻole o ka plasma.
Hōʻuluʻulu manaʻo
I kēia mau lā,berberinehiki ke synthesized artificial a hoʻololi ʻia e nā ʻano hana ʻenehana kristal. Loaʻa iā ia ke kumukūʻai haʻahaʻa a me ka ʻenehana kiʻekiʻe. Me ka hoʻomohala ʻana o ka noiʻi olakino a me ka hohonu o ka noiʻi kemika, ʻoiaʻiʻo e hōʻike ʻo berberine i nā hopena lāʻau lapaʻau. Ma ka lima hoʻokahi, ʻaʻole i loaʻa wale i ka berberine nā hopena kupaianaha i ka noiʻi pharmacological kuʻuna i ka antibacterial, antiviral, anti-inflammatory, anti-tumor, anti-diabetic, a me ka mālama ʻana i nā maʻi cardiovascular a me ka cerebrovascular, akā ua loaʻa ka nānā nui ʻana i kāna hoʻolālā ʻenekini aniani a me ka morphological analysis. Ma muli o kona koʻikoʻi koʻikoʻi a me ka haʻahaʻa haʻahaʻa a me nā hopena ʻaoʻao, loaʻa iā ia ka mana nui i ka noi lapaʻau a he ākea ākea. Me ka hoʻomohala ʻana o ka biology cell, e hoʻomaʻamaʻa ʻia ke ʻano lāʻau lapaʻau o berberine mai ka pae cellular a hiki i nā pae molecular a me nā pae kiʻekiʻe, e hāʻawi ana i ke kumu kumu no kāna noi lapaʻau.
● Hoʻolako hou ʻo NEWGREENBerberine/ Liposomal Berberine Pauka/Kapu/Papa
Ka manawa hoʻouna: Oct-28-2024
