● He ahaβ-NAD ?
ʻO β-Nicotinamide Adenine Dinucleotide (β-NAD) kahi coenzyme kī i loaʻa i loko o nā cell ola a pau, me kahi molecular formula o C₂₁H₂₇N₇O₁₄P₂, a me ke kaumaha molekala o 663.43. Ma ke ʻano he mea lawe kumu nui o ka redox reactions, ua hoʻoholo pololei kona ʻike i ka pono o ka metabolism ikehu cellular a ʻike ʻia ʻo ia ʻo "cellular energy currency".
Nā hiʻohiʻona mahele kūlohelohe:
ʻO nā ʻokoʻa o ka ʻili: ʻO ka ʻike i loko o nā pūnaʻi myocardial ka mea kiʻekiʻe loa (e pili ana i 0.3-0.5 mM), ukali ʻia e ke ake, a me ka haʻahaʻa loa i ka ʻili (e emi ana ma 50% i kēlā me kēia 20 makahiki me ka makahiki);
ʻO ke ʻano o ke ola: me ke ʻano oxidized (NAD⁺) a me ke ʻano i hoʻemi ʻia (NADH), a ʻo ke koena ikaika o ka ratio ma waena o nā mea ʻelua e hōʻike ana i ke ʻano o ka metabolism cellular.
● Palekana Radiation oβ-NAD.
E hoʻonui i ka nui o ke ola ʻana o nā cell stem hematopoietic ma hope o ka hoʻolaha ʻana i ka radiation e 3 mau manawa, a loaʻa i ka manaʻo nui mai ka papahana olakino ākea a NASA.
Kumu hoʻomākaukau: Mai ka hoʻoheheʻe ʻana i ka biological a hiki i ka synthetic biology revolution
1. Keʻano unuhi kuʻuna
Nā mea waiwai: nā mea hū (maʻiʻo 0.1% -0.3%), ke ake o nā holoholona;
Kaʻina hana: ultrasonic crushing → ion exchange chromatography → freeze drying,β-NADmaʻemaʻe ≥ 95%.
2. Enzyme catalytic synthesis (ka hana nui)
Lapaʻa: Nicotinamide + 5'-phosphoribosyl pyrophosphate (PRPP);
Pōmaikaʻi: Hiki i ka ʻenehana enzyme Immobilized ke hoʻonui i ka hua o β-NAD i 97%.
3. Biology Synthetic (kuhikuhi e hiki mai ana)
Gene-edited Escherichia coli:He kānana ʻenekinia i kūkulu ʻia e ChromaDex, USA, me ka hua fermentation o 6 g/L;
Moʻomeheu cell plant: ʻO ka ʻōnaehana aʻa huluhulu paka e ʻike i ka hana nui o NAD precursor NR.
● He aha nā pōmaikaʻi o kaβ-NAD?
1. Anti-kahiko kumu hana
E ho'ā i nā Sirtuins:Hoʻonui i ka hana SIRT1/3 e 3-5 mau manawa, hoʻoponopono i ka pōʻino DNA, a hoʻonui i ke ola hū e 31%;
Ka mana o ka mitochondrial:Hōʻike nā haʻawina hoʻomaʻamaʻa i ka poʻe o 50-70 mau makahiki e hoʻonui i ka 500 mg NMN i kēlā me kēia lā, a piʻi aʻe ka hana ATP muscle ma 25% ma hope o 6 pule.
2. Neuroprotection
ʻO ka maʻi o Alzheimer:ʻO ka hoʻihoʻi ʻana i nā pae neuronal NAD⁺ hiki ke hōʻemi i ka deposition β-amyloid, a hoʻomaikaʻi ʻia ka hana cognitive o nā kiʻi kiʻi e 40%;
ʻO ka maʻi o Parkinson: β-NADE pale aku i nā neurons dopaminergic ma o ka pale ʻana o PARP1.
3. Hoʻopili maʻi metabolic
Diabetes:Hoʻonui i ka naʻau o ka insulin, hōʻike nā hoʻokolohua ʻiole obese i ka emi ʻana o 30% o ke kō koko;
Ka mālama ʻana i ka maʻi cardiovascular:E hoʻomaikaʻi i ka hana endothelial, a hoʻemi i ka wahi o nā plaque atherosclerotic e 50%.
● He aha nā noi oβ-NAD?
1. Kahua lapaʻau
Nā lāʻau lapaʻau kūʻē i ka wā kahiko: Ua hōʻoia ʻia nā hoʻomākaukau NMN he nui e like me nā lāʻau makua ʻole e ka FDA no ka myopathy mitochondrial;
Nā maʻi neurodegenerative: Ua komo ka NAD⁺ intravenous injection i nā hoʻokolohua lapaʻau Phase II (nā hōʻailona no ka maʻi o Alzheimer).
2. Nā meaʻai hana
Pākuʻi waha: β-NADe like me NAD precursor (NR/NMN) capsules loaʻa nā kūʻai makahiki ma mua o $ 500 miliona.
Mea ai haʻuki:E hoʻomaikaʻi i ka hoʻomanawanui o ka poʻe haʻuki, a aia kekahi mau NAD optimizers ma ka mākeke e hoʻomaikaʻi i ka hana haʻuki.
3. ʻO nā mea hoʻonaninani
ʻO ke kumu kūʻē i ka wā kahiko:0.1%-1% NAD⁺ paʻakikī, hoʻāʻo ʻia e hōʻemi i ka hohonu wrinkle e 37%;
Ka mālama poʻo:E ho'ā i nā pūnaewele stem follicle lauoho, a hoʻohui i nā mea hoʻonui NAD i ka shampoo anti-hair loss shampoo.
4. Mahiai a me ka noiʻi ʻepekema
Ola holoholona:ʻO ka hoʻohui ʻana i nā precursors NAD e lūlū i ka hānai e hoʻonui i ka nui o nā puaʻa e 15%;
ʻIke olaola:Hoʻohana ʻia ka ratio NAD/NADH ma ke ʻano he hōʻailona o ke kūlana metabolic cell no ka nānā ʻana i ka maʻi maʻi mua.
●Hoolako NU HOUβ-NADPauda
Ka manawa hoʻouna: Iune-17-2025
