● MeneneSclareol ?
Sclareol, sunan sinadarai (1R,2R,8aS) -decahydro-1- (3-hydroxy-3-methyl-4-pentenyl) -2,5,5,8a-tetramethyl-2-naphthol, tsarin kwayoyin C₂₀H₃₆O₂, kwayoyin nauyi 308.2507-308AS Yana da wani fili diterpenoid bicyclic, tare da bayyanar farin crystalline foda, narkewa batu 95-105 ℃, tafasar batu 398.3 ℃, insoluble a cikin ruwa, da kuma sauƙi mai narkewa a cikin Organic kaushi. Babban halayensa shine cewa yana da ƙamshi mai ɗorewa mai kama da ambergris, tare da ƙamshi mai ƙaƙƙarfan ƙamshi da yaduwa mai ƙarfi, yana mai da shi kyakkyawan kayan da za a iya amfani da shi don manyan turare.
Tushen dabi'a galibi shine inflorescence da mai tushe da ganyen shukar Lamiaceae Salvia Sclarea L., wanda ake nomawa a kan babban sikeli a cikin tuddai masu tsayi kamar arewacin Shaanxi da Honghe, Yunnan, China. Saboda babban bambancin zafin jiki tsakanin dare da rana da zafi mai dacewa, clarysol a cikin waɗannan wuraren da ake samarwa yana da tsafta da ƙamshi mai tsafta.
Akwai manyan hanyoyi da yawa don haɗa sclareol:
1. Sinadarin kira
Gabaɗaya,clareolAna amfani da tsantsa azaman albarkatun ƙasa don hakar da tsarkakewa. Ragowar sclareol bayan hakar mai an narkar da shi a cikin ethanol, kuma sclareol yana haɓaka a cikin nau'in farin allura bayan daskarewa mai ƙarancin zafi, tacewa, kunna carbon jiyya, dilution da sauran matakai. Bayan bushewar centrifugal, bushewar injin, murƙushewa da nunawa, ana iya samun sclareol tare da babban abun ciki na barasa.
2. Biosynthesis
Gina masana'anta yisti cell masana'anta: A cikin binciken, synthases guda biyu TPS da LPPs a cikin sage an fara haɗa su zuwa kwayar yisti, wanda ya haɓaka samar da ingantaccenclareol. Sannan an haɗa N-terminus na TPS-LPPS zuwa wani ɓangaren furotin mai ɗaure maltose don ƙara haɓaka kwanciyar hankali na enzyme da ƙara yawan amfanin ƙasa. Sa'an nan kuma, ƙungiyar bincike ta raba dukkanin hanyar rayuwa zuwa sassa uku: tsakiyar hanyar rayuwa don samar da acetyl coenzyme A, hanyar isoprenoid biosynthesis da tsarin tsarin tsarin tsarin. Ta wurin maidowa da share wasu kwayoyin halittar da ke da alaƙa, an gina wani nau'in chassis wanda zai iya samar da acetyl-CoA da NADPH yadda ya kamata, kuma an ƙara haɓaka yawan amfanin sclareol ta hanyar wuce gona da iri. A ƙarshe, an yi nazarin tasirin kowane nau'i akan haɗin sclareol ta hanyar bayanin martaba na ƙirar injiniya, kuma an gano cewa nau'ikan nau'ikan uku suna da tasirin daidaitawa. An gudanar da fermentation na Fed-batch a cikin filaye masu girgiza da bioreactors, kuma a ƙarshe an haɗa sclareol da kyau a cikin Saccharomyces cerevisiae ta amfani da glucose azaman albarkatun ƙasa, tare da yawan amfanin ƙasa na 11.4 g/L.
●Menene TheAmfaniNa Sclareol ?
Binciken da aka yi kwanan nan ya bayyana ayyukan nazarin halittu masu yawa na clareol, musamman a fagen cututtuka na tsarin juyayi na tsakiya:
1. Anti-mai kumburi da neuroprotective:
Yana hana yawan kunna microglia, yana rage matakan abubuwan kumburi TNF-a da IL-1β, yana kawar da rikicewar motsi a cikin mice samfurin Parkinson, kuma yana kare neurons na dopamine;
Inganta aikin fahimi a cikin samfuran cututtukan Alzheimer. Matsakaicin 50-200mg/(kg·d) zai iya hana kunnawar astrocytes a cikin kwakwalwa kuma ya rage ƙaddamar da furotin β-amyloid.
2. Ayyukan Anticancer:
Yana da cytotoxicity mai ƙarfi zuwa layin ƙwayoyin kansa irin su cutar sankarar linzamin kwamfuta (P-388) da ciwon daji na epidermal na ɗan adam (KB), kuma yana hana haɓakar ƙari ta hanyar haifar da apoptosis.
3. Antibacterial da antioxidant:
Yana da nau'in nau'i mai yawa na hana haɓakar ƙwayoyin cuta, kuma ingancin maganin antioxidant ya ninka sau 50 na bitamin E, wanda ya dace da suturar raunuka da samfuran kula da fata masu tsufa.
●Menene TheAikace-aikaceOf Sclareol ?
1. Masana'antar dandano da ƙamshi:
A matsayin ainihin albarkatun kasa don haɓakar ambergris, yana maye gurbin ambergris na halitta daga kifayen maniyyi masu haɗari. Ana amfani da ɗan ƙaramin adadin kai tsaye a cikin manyan turare don ba wa ƙamshin daɗaɗɗen jin daɗi.
2. Binciken Pharmaceutical da haɓakawa:
Cutar cutar Alzheimer / Magungunan cututtukan Parkinson: capsules na baka ko allurai sun shiga bincike na musamman, wanda ke yin niyya kan hana neuroinflammation;
Maganin rigakafin ciwon daji: haɗe tare da magungunan chemotherapy don haɓaka kashe ƙwayoyin tumor.
3. Kayan shafawa da abinci:
Abubuwan kula da fata na rigakafin tsufa: ƙara 0.5% -2% don hana ɗaukar hoto da rage ultraviolet erythema;
Abubuwan kiyayewa na halitta: ana amfani da su a cikin abinci mai mai don tsawaita rayuwa, kuma sun fi aminci fiye da samfuran roba.
●NEWGREEN Samar da Ingantaccen inganciSclareolFoda
Lokacin aikawa: Yuli-18-2025
