● MeneneChenodeoxycholic acid ?
Chenodeoxycholic acid (CDCA) yana daya daga cikin manyan abubuwan da ke tattare da bile vertebrate, wanda ya kai kashi 30% -40% na bile acid din dan adam, kuma abun cikinsa yana da girma a cikin bile na geese, agwagi, alade da sauran dabbobi.
Nasarorin da aka samu a fasahar hakar zamani:
Supercritical CO₂ hakar: hakar a ƙarƙashin ƙananan zafin jiki da yanayin matsa lamba don kauce wa ragowar sauran ƙarfi, kuma tsarki zai iya kaiwa fiye da 98%;
Hanyar fermentation na ƙananan ƙwayoyin cuta: ta yin amfani da nau'o'in injiniya na kwayoyin halitta (irin su Escherichia coli) don haɗa CDCA, an rage farashin da 40%, wanda ya dace da yanayin masana'antun magunguna na kore;
Hanyar haɗakar sinadarai: ta amfani da cholesterol azaman mafari, ana samun shi ta hanyar halayen matakai da yawa, wanda ya dace da samfuran samfuran magunguna masu tsafta.
Jiki da sunadarai Properties naChenodeoxycholic acid :
Sunan sinadarai: 3α,7a-dihydroxy-5β-cholanic acid (Chenodeoxycholic Acid)
Tsarin kwayoyin halitta: C₂₄H₄₀O₄
Nauyin kwayoyin halitta: 392.58 g/mol
Bayyanar: farin crystalline foda
Solubility: dan kadan mai narkewa a cikin ruwa, sauƙi mai narkewa a cikin ethanol, ether, chloroform
Matsayin narkewa: 165-168 ℃
Kwanciyar hankali: mai kula da haske da zafi, yana buƙatar a sanyaya shi daga haske (2-8 ℃)
● Menene fa'idodinChenodeoxycholic acid ?
1. Narkar da Duwatsun Cholesterol
Mechanism: hana hanta HMG-CoA reductase, rage cholesterol kira, inganta bile acid mugunya, da kuma sannu a hankali narkar da cholesterol gallstones;
Bayanan asibiti: 750mg CDCA kowace rana don watanni 12-24, yawan rushewar gallstone zai iya kaiwa 40%-70%.
2. Maganin Biliary Cholangitis (Pbc)
Magungunan layi na farko: FDA ta amince da Chenodeoxycholic Acid CDCA don PBC, inganta alamun aikin hanta (ALT/AST an rage da fiye da 50%);
Magungunan haɗin gwiwa: haɗuwaChenodeoxycholic acidtare da ursodeoxycholic acid (UDCA), ingancin yana inganta da 30%.
3. Ka'idar Cututtukan Metabolic
Rage lipids na jini: rage yawan ƙwayar ƙwayar ƙwayar cuta (TC) da ƙananan lipoprotein (LDL);
Anti-ciwon sukari: inganta haɓakar insulin, gwaje-gwajen dabbobi sun nuna cewa sukarin jini yana raguwa da kashi 20%
4. Ka'idojin rigakafin kumburi da rigakafi
Hana hanyar NF-κB kuma rage sakin abubuwa masu kumburi (TNF-α, IL-6);
Gwajin gwaje-gwaje na asibiti sun nuna cewa haɓakar haɓakar fibrosis na hanta a cikin marasa lafiya da cututtukan hanta mara-giya (NAFLD) ya wuce 60%.
● Menene Aikace-aikace NaChenodeoxycholic acid ?
1. Filin Kiwon Lafiya
Maganin gallstone: CDCA Allunan (250mg / kwamfutar hannu), kashi na yau da kullum 10-15mg / kg;
Jiyya na PBC: shirye-shiryen fili tare da UDCA (irin su Ursofalk®), tallace-tallace na shekara-shekara na duniya ya wuce dalar Amurka miliyan 500;
Binciken Anti-tumor: hana yaduwar kwayar cutar kansar hanta ta hanyar daidaita masu karɓar FXR, shigar da gwaji na asibiti na Phase II.
2. Abinci masu aiki da Kayayyakin Lafiya
Allunan kare hanta: dabarar fili (CDCA + silymarin), rage lalacewar hanta barasa;
Lipid-lowering capsules: synergistic tare da jan yisti shinkafa tsantsa don daidaita jini lipid metabolism.
3. Kiwon Dabbobi Da Kiwo
Additives ciyar: inganta dabbobi da kaji mai mai, rage yawan kitsen ciki;
Lafiyar kifin: ƙara 0.1%chenodeoxycholic aciddon haɓaka jurewar cututtukan carp da haɓaka ƙimar rayuwa da kashi 15%.
4. Kayayyakin Kayayyaki Da Kulawa Na Kai
Jigon anti-mai kumburi: 0.5% -1% ƙari, inganta kuraje da jin daɗin fata;
Kula da gashin kai: hana Malassezia kuma rage haɓakar dandruff.
Daga hakar bile na al'ada zuwa haɗin ƙwayoyin ƙwayoyin cuta, chenodeoxycholic acid yana jurewa daga "kayan aikin halitta" zuwa "maganin madaidaicin". Tare da zurfafa bincike game da cututtuka na rayuwa da ƙwayoyin cuta, CDCA na iya zama ainihin albarkatun kasa don maganin cututtukan hanta, abinci mai aiki da kayan aiki, wanda ke jagorantar sabon motsi na masana'antar kiwon lafiya na biliyan 100.
● SABON KYAUTAChenodeoxycholic acidFoda
Lokacin aikawa: Juni-11-2025
