●Menene Bilirubin?
Bilirubin wani samfur ne na bazuwar ƙwayoyin jajayen jinin tsufa. Kimanin ƙwayoyin jajayen jini miliyan biyu ne ke warwatse a cikin sa a kowace rana. Haemoglobin da aka saki yana jujjuya shi ta hanyar enzymatically zuwa mai-mai narkewa a kaikaice bilirubin, wanda sai a juye shi zuwa bilirubin kai tsaye mai narkewa ta ruwa ta hanta sannan daga karshe ya fita zuwa cikin hanji ta bile. Duk wani rashin daidaituwa a cikin wannan sarkar na rayuwa (kamar hemolysis, lalacewar hanta ko toshewar bile duct) na iya haifar da tarin bilirubin kuma yana haifar da jaundice.
Binciken na baya-bayan nan ya gano cewa lokacin da adadin bilirubin ya kasance≥17.05μmol/L, ana iya toshe haɗin gwiwa tsakanin ciwon sukari da bugun jini, kuma haɗarin bugun jini a cikin maza masu ciwon sukari ya ragu da sau 2.67. Hanyar ita ce ta hana haɓakar furotin C-reactive mai girma da ƙwayar ƙwayar cuta ta tsarin rigakafi, yana sanya birki a kan "guguwa mai kumburi".
Ana fitar da Bilirubin daga hanta na alade da shark, gallbladder na shanu da kuma kwakwalwa. Mun sami ci gaba ta hanyar sabbin fasahohi:
Supercritical CO₂ hakar: riƙe abubuwa masu aiki a ƙarƙashin ƙananan yanayin zafi, guje wa ragowar sauran ƙarfi, da haɓaka tsabta zuwa fiye da 98%;
Halittar enzymatic hydrolysis tsari: juyawar jagora na bilirubin glycosides zuwa aglycones mai aiki, yana haɓaka bioavailability da 50%.
●Menene fa'idodinBilirubin ?
1. Antioxidant kariya
Bilirubin wani muhimmin antioxidant ne na endogenous a cikin jiki, wanda zai iya kawar da radicals kyauta (kamar superoxide da hydrogen peroxide) yadda ya kamata kuma ya rage lalacewar danniya na oxidative ga membranes cell, sunadarai da DNA. Nazarin ya nuna cewa ƙananan ƙwayoyin bilirubin na iya haɓaka garkuwar tantanin halitta daga lalacewar oxidative ta hanyar kunna hanyoyin siginar antioxidant (kamar hanyar Nrf2), kuma yana iya ma rage haɗarin atherosclerosis da cututtukan neurodegenerative.
2. Immunomodulatory aiki
Bilirubinzai iya daidaita martanin rigakafi ta hanyar hana sakin abubuwan da ke haifar da kumburi (irin su TNF-a da IL-6). Zai iya rage lalacewa ga kyallen takarda da ke haifar da kumburi mai yawa yayin da yake kiyaye ma'auni na tsarin rigakafi. Misali, haɓakar bilirubin mai sauƙi a cikin jaundice na physiological na jarirai na iya taimakawa wajen rage haɗarin kamuwa da cuta ta wannan hanyar. Koyaya, ƙima mai yawa na iya hana ayyukan ƙwayoyin rigakafi da haɓaka kamuwa da cuta.
3. Cell da neuroprotection
Bilirubin yana da tasirin kariya na musamman akan tsarin juyayi. Zai iya ƙetare shingen kwakwalwar jini da kuma kare neurons daga ischemia ko raunuka masu lalacewa ta hanyar hana glutamate excitotoxicity da rage lalacewar oxidative. Bugu da ƙari, bilirubin kuma zai iya rage lalacewar ƙwayoyin hanta, ƙwayoyin myocardial, da dai sauransu a ƙarƙashin hypoxia ko toxin, da kuma kula da aikin gabobin.
4. Inganta metabolism da kuma zagayowar excretion
Tsarin metabolism nabilirubinbabbar hanyar haɗi ce a sake yin amfani da haemoglobin a cikin jiki. Bayan haemoglobin a cikin tsufa jajayen ƙwayoyin jini ya bazu zuwa bilirubin, ana buƙatar hanta a haɗa shi kuma a fitar da shi cikin hanji tare da bile. Kwayoyin cuta na hanji suna mayar da shi zuwa urobilinogen, wanda wani bangare nasa ya sake dawowa (enterohepatic circulation), sauran kuma ana fitar da shi da najasa. Wannan sake zagayowar ba wai kawai yana taimakawa wajen cire sharar rayuwa ba, har ma yana hulɗa tare da flora na hanji don shafar ma'auni na rayuwa gaba ɗaya.
5. Cutar da matakan da ba al'ada ba
Yawan bilirubin: Yana iya haifar da jaundice (yellowing na fata da sclera), wanda ya zama ruwan dare a cikin hanta, toshewar biliary ko cututtukan hemolytic. Lokacin da bilirubin kyauta ya yi yawa, zai iya wucewa ta shingen jini-kwakwalwa kuma ya haifar da kernicterus na jariri (lalacewar kwakwalwa).
Karancin bilirubin: Bincike na baya-bayan nan ya gano cewa ƙarancin haɓakar bilirubin na iya samun sakamako mai karewa, yayin da ƙananan matakan na iya haɗuwa da haɗarin cututtukan zuciya da cututtukan zuciya, amma takamaiman tsarin har yanzu yana buƙatar yin nazari.
●Menene Fadada Aikace-aikacen Likita Na Bilirubin ?
1. Core pharmaceutical albarkatun kasa
Bilirubin shine babban sinadarin bezoar na wucin gadi kuma ana amfani dashi a cikin magunguna sama da 130, kamar su cututtukan zuciya da jijiyoyin jini (85% mai tasiri wajen kawar da cututtukan zuciya na jijiyoyin zuciya) da shirye-shiryen ƙa'ida.
2. Shirye-shiryen Nano (BRNPs)
Ta hanyar fasahar nanocarrier, inganci da niyya na bilirubin an inganta sosai:
Ciwon ciki mai tsanani: chitosan-bilirubin (CS-BR), yana hana ɓoyewar abubuwan kumburi kuma yana inganta farfadowa na mucosal.
Hanta mai mai mara-giya: polyethylene glycol-bilirubin (PEG-BR), yana rage kitsen hanta da kashi 30%, kuma yana rage triglycerides da kashi 40%.
Psoriasis: hydrogelbilirubin, inganta fata raunuka, ba tare da tsarin guba na corticosteroids
Buga: TRPM2 mai hanawa tashar A23, yana toshe bilirubin neurotoxicity kuma yana rage girman infarct.
Sauran aikace-aikacen bilirubin: kiwon dabbobi, kariyar muhalli da samfuran aiki
Aquaculture: Ƙara 4% bilirubin don ciyarwa yana ninka samar da farin shrimp kuma yana ƙara yawan nauyin kifin kifi da 155.1%;
Abinci mai aiki: Ruwa na baka na Anti-glycation, haɗe tare da kaddarorin antioxidant na bilirubin don jinkirta tsufan fata.
●NEWGREEN Supply BilirubinFoda
Lokacin aikawa: Juni-09-2025
