Andrographis Paniculata Extract: Ƙarfin Maganin Kwayoyin cuta Da Ƙunƙarar Ganye.

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Andrographis paniculata, wanda kuma aka sani da "farin ciki na lokaci ɗaya" da "ciyawa mai ɗaci", tsire-tsire ne na shekara-shekara na dangin Acanthaceae. Ya fito ne daga Kudancin Asiya kamar Indiya da Sri Lanka, kuma yanzu an rarraba shi a wurare masu zafi da zafi kamar Guangdong da Fujian na kasar Sin. Dukan tsire-tsire suna ɗanɗano mai ɗaci sosai, tare da tushe mai murabba'i, ganyen kishiyar, da lokacin fure na Agusta-Satumba. Magungunan gargajiya na kasar Sin na amfani da tasirinsa na kawar da zafi da kawar da guba, sanyaya jini da rage kumburi don magance mura, zazzabi, ciwon ciki, ciwon ciki da cizon maciji. Masana'antu na zamani suna fitar da kayan aiki masu aiki daga mai tushe da ganye ta hanyar hakar CO₂ na supercritical da fasahar bio-enzymatic hydrolysis don yin daidaitattun foda tare da abun ciki na andrographolide na 8% -98%, yana haɓaka haɓakawa daga magungunan gargajiya na gargajiya zuwa albarkatun ƙasa.

Babban aiki sinadaran naAndrographis Paniculata ExtractsSu ne mahadi lactone diterpenoid, lissafin 2% -5% 24, yafi ciki har da:

1.  Andrographolide:Tsarin kwayoyin halitta C₂₀H₃₀O₅, lissafin kashi 30% -50%, shine babban abu mai aiki don maganin rigakafi da anti-inflammatory.
2.  Dehydroandrographolide:kwayoyin dabara C₂₀H₂₈O₄, narkewa batu 204℃, tare da gagarumin anti-tumor aiki.
3. 14-Deoxyandrographolide:dabarar kwayoyin C₂₀H₃₀O, tare da ingantaccen inganci akan leptospirosis.
4. Neoandrographolide:kwayoyin dabara C₂₆H₄₀O, mai kyau ruwa solubility, dace da baka shirye-shirye.

Bugu da kari, flavonoids, phenolic acid da maras tabbas mai aka gyara synergistically inganta antioxidant da immunomodulatory ayyuka.

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1. Immunomodulation And Anti-Infection

Antibacterial da antiviral: Andrographolide yana da adadin hanawa sama da 90% akan Staphylococcus aureus da Shigella dysenteriae, kuma tasirin sa na asibiti wajen magance ciwon dajin bacillary yana kama da chloramphenicol. Cire ruwanta na iya rage kamuwa da mura da kashi 30% kuma ya rage lokacin sanyi da kashi 50%.

Inganta rigakafi: Ta hanyar kunna macrophages da T lymphocytes, zai iya ƙara matakin CD4⁺ lymphocytes a cikin marasa lafiya na HIV (bayanan asibiti: 405→501/mm³, p=0.002).

2. Anti-Tumor And Angiogenesis Inhibition

Kai tsaye anti-tumor: Dehydroandrographolide zai iya hana ci gaban W256 da aka dasa ciwace-ciwacen daji kuma ya hana yaduwar kwayar cutar kansa ta hanyar dogaro da kashi.

Anti-angiogenesis: Andrographolide yana toshe ciwon angiogenesis ta hanyar rage ka'idodin VEGFR2 da kuma hana hanyar siginar ERK/p38, tare da IC₅₀ na 100-200μM.

3. Metabolism Da Kariyar Gabas

Kariyar hanta da raguwar lipid: Andrographolide yana kula da matakan glutathione kuma yana rage malondialdehyde (MDA) a cikin samfurin raunin hanta na tetrachloride da 40%, wanda ya fi silymarin kyau.

Kariyar zuciya: Yana daidaita ma'aunin nitric oxide/endothelin, yana jinkirta atherosclerosis, kuma yana rage matakan lipid na jini a cikin zomayen gwaji.

4. Anti-mai kumburi da Antioxidant

Ruwan tsantsa daga cikin tushe yana da ikon da ya fi ƙarfin don lalata radicals kyauta (IC₅₀ = 4.42μg / mL), wanda shine sau 4 mafi inganci fiye da antioxidants na roba kuma ya dace da cututtukan cututtuka na kullum.

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1. Magani Da Magani

Magungunan rigakafin cututtuka: ana amfani da su don ciwon daji na kwayan cuta, allurar ciwon huhu da shirye-shiryen baki don pharyngitis, tare da adadin maganin asibiti sama da 85%.

Magungunan da aka yi niyya don rigakafin ƙari: Abubuwan Andrographolide “Andrographine” sun shiga gwajin asibiti na Phase II don cutar sankarar bargo da kuma ciwace-ciwace.

Gudanar da cututtuka na yau da kullum: maganin maganin ciwon sukari na retinopathy (0.5-2mg/kg/ day) da rheumatoid arthritis (1-3mg/kg/ day).

2. Kiwon Dabbobi Da Koren Kiwo

Madadin maganin rigakafi: Compound Andrographis paniculata feed additives yana rage yawan gudawa na alade kuma yana ƙara yawan rayuwa na broilers; ƙara 4% cirewa zuwa abincin carp, ƙimar ƙimar nauyi ya kai 155.1%, kuma an inganta ƙimar canjin abinci zuwa 1.11.

Rigakafin cututtuka da sarrafawa: allurar Andrographis paniculata tana maganin ciwon huhu da enteritis, tare da adadin magani na 90% da adadin mace-mace na 10%.

3. Lafiyayyan Abinci Da Sinadaran Kullum

Abinci mai aiki: Andrographis paniculatacirecapsules (200mg kowace rana) ana ƙaddamar da su a kasuwannin Turai da Amurka don tsarin rigakafi da rigakafin sanyi.

Kayayyakin kula da fata: Ƙara zuwa abubuwan da ke hana kumburin kumburin rana da abubuwan kariya na rana don sauƙaƙa lalacewar UV da jajayen fata mai laushi.

4. Nasara A Filaye masu tasowa

Magungunan anti-angiogenic: Haɓaka shirye-shiryen da aka yi niyya don ciwace-ciwacen ciwace-ciwacen ƙwayar cuta da ciwon sukari na retinopathy ya zama babban jagorar ilimin halitta.

Kiwon lafiyar dabbobi: Abubuwan rigakafin kumburi da rigakafin rigakafi don karnuka da kuliyoyi ana ƙaddamar da su a cikin kasuwar Arewacin Amurka, tare da haɓakar haɓakar shekara-shekara na 35%.

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